In response to thyroid hormone, increased Ca 2+ concentration and AMPK activation via CaMKK2 was observed in adipocytes hypomorphic for Lkb1, an alternative upstream kinase for AMPK activation . Meanwhile, CaMKK2 reportedly regulates AMPK action in response to glucagon, which then phosphorylates acetyl-CoA carboxylase 1 (ACC1) in adipocytes.

有研究表明，肿瘤细胞脱离基质之后，CaMKK2迅速激活AMPK，使细胞准备应对能源危机，从而抵抗失巢凋亡（[5]: J Biol Chem. 2016）。 基质剥夺通过CaMKKβ激活 AMPK。

2023年9月1日 · CaMKK2 protein is undetectable in skeletal muscle. The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various metabolic processes such as insulin-independent glucose uptake in skeletal muscle.

当上游激酶 camkk2 被细胞内钙离子激活， lkb1 与 strad 和 mo25 组成异源三聚体时，ampk机制激活。导致ampk活化的因素有氧气应激、葡萄糖饥饿、运动以及线粒体毒物等，激活ampk的药物主要为小分子变构激活剂（左侧）和amp仿制药aicar。

2013年4月10日 · We show that increased intracellular calcium [Ca²⁺](i) induced by NMDA receptor activation or membrane depolarization activates AMPK in a CAMKK2-dependent manner. CAMKK2 or AMPK overactivation is sufficient to induce dendritic spine loss.

We demonstrate that pharmacological inhibition or genetic loss of CaMKK2 does not affect contraction-stimulated AMPK phosphorylation and activation, as well as glucose uptake in skeletal muscle. Previously observed inhibitory effect of STO-609 on AMPK activity and glucose uptake is likely due to off …

CAMKK2 在前列腺癌中通过 CAMKK2/AMPK 通路参与增加的细胞增殖和迁移以及在卵巢癌中激活 AKT。 尽管CAMKK2是一个非常重要的分子，但目前缺乏CAMKK2信号通路的公共资源。 因此，我们从已发表的文献中对与 CAMKK2 相关的信号事件进行了详细的数据挖掘和记录，并开发了 CAMKK2 信号的综合反应图。 这导致对属于 CAMKK2 信号通路的 285 个反应进行编目，其中包括 33 个蛋白质-蛋白质相互作用、74 个翻译后修饰、7 个蛋白质易位事件和 22 个激活/抑制事 …

2012年9月14日 · In addition to its role in these enzymatic cascades, CaMKK2 is also a physiologically relevant upstream activator of the AMP-activated protein kinase (AMPK) (5, 6, 7), and one role for this CaMKK2-AMPK complex is the regulation of energy balance by acting in the hypothalamus (8).

2018年7月3日 · Stress fiber maturation requires mechanosensitive activation of 5′AMP-activated protein kinase (AMPK), which phosphorylates vasodilator-stimulated phosphoprotein (VASP) to inhibit actin polymerization at focal adhesions.

2018年12月15日 · Here, we show that Camkk2 deletion or pharmacologic inhibition protects against prostate cancer development in a preclinical mouse model that lacks expression of prostate-specific Pten. In contrast, deletion of AMP-activated protein kinase (Ampk) β1 resulted in earlier onset of adenocarcinoma development.