Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene. CYP3A5 encodes a member of the cytochrome P450 superfamily of enzymes. Like most of the cytochrome P450, the CYP3A5 is expressed in the prostate and the liver. [5] .

We recently tested you for the CYP3A5 gene. This info sheet explains the test, your results, and what your doctor may do with that information. Genes are pieces of DNA that we inherit from our parents. Genes provide the instructions to make our bodies look and work as they do. Some genes affect the way medicines work in the body.

Key points about CYP3A5. CYP3A5 is part of the cytochrome P450 family of enzymes that helps the body break down certain medicines. A pharmacogenomic test can help your medical team know well your CYP3A5 enzyme will work. Some people may need a change in medicine dose based on CYP3A5 enzyme activity.

CYP3A5 is the predominant CYP3A protein in human kidneys, lungs, blood, and pituitary and is also present in liver and intestinal tissues [5,26]. CYP3A5 also shows interindividual differences—from severalfold to hundreds of times—in terms …

CYP3A, a key member of the cytochrome P450 (CYP450) superfamily, is integral to drug metabolism, processing a substantial portion of medications. Their role in drug metabolism is particularly prominent, as CYP3A4 and CYP3A5 metabolize …

Dec 24, 2024 · CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Drug Metabolism, Poor, Cyp2c19-Related. Among its related pathways are Metapathway biotransformation Phase I and II and Clomipramine Pathway, Pharmacokinetics.

Keywords: CYP3A family, CYP3A4, CYP3A5, drug metabolism, crystal structure, small molecule modulators. 1. Introduction. The human cytochrome P450 3A (CYP3A) family is part of the broader CYP superfamily of heme-containing enzymes.

Sep 9, 2021 · CYP3A5 is an enzyme that removes drugs and toxins from the body, but many people don't even have it. Learn about its roles and genetic variants.

CYP3A5 is a gene that encodes an enzyme responsible for the metabolism of more than 35% of the drugs prescribed worldwide. You might find these chapters and articles relevant to this topic. CYP3A5 is similar to CYP3A4 and metabolizes similar substrates, but its activity is diminished.

Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human gene locus. [2] [3] A homologous locus is found in mice.[4]The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, …

Feb 24, 2022 · Variable CYP3A5 activity is of clinical importance regarding tacrolimus metabolism. This GeneFocus provides a CYP3A5 gene summary with a focus on aspects regarding standardized nomenclature.

Learn about the CYP3A5 gene, its function in drug metabolism, genetic variations, and their impact on drug response. Explore CYP3A5 testing and personalized medicine.

Recent research on CYP3A5 in vitro and in humans has provided discordant information on whether CYP3A5 plays a significant role in the metabolism of CYP3A substrates in vivo. For example, six separate studies have reported CYP3A5 to contribute between 2 and 60% of the total hepatic CYP3A.

Based on homozygosity for the CYP3A5*3 allele, individuals were divided into CYP3A5 non-expressors (CYP3A5*3/*3) and CYP3A5 expressors (CYP3A5*1/*3 and CYP3A5*1/*1). CYP3A5*3 is the most common allele in European and Asian populations, but it is the minor allele in people of African ancestry.

We report the induction of CYP3A5 mRNA in 13 of 16 hepatocyte preparations exposed to rifampin. Furthermore, induction of CYP3A5 mRNA was observed in intestinal biopsies in three of eight probands following exposure to the antibiotic.

Jan 9, 2014 · Metabolism by cytochrome P4503A (CYP3A) is the most prevalent clearance pathway for drugs. Designation of metabolism by CYP3A commonly refers to the potential contribution by one or both of two enzymes, CYP3A4 and CYP3A5.

Mar 13, 2025 · The CYP3A5 A6986G SNP has been reported to cause alterations in the metabolism of drugs like cyclophosphamide, vincristine and prednisone (used in the R-CHOP regimen for DLBCL), and therefore impact chemotherapy responses in both solid and hematological cancers.

Comparison with the CYP3A5–ritonavir complex confirmed conserved CYP3A5 structural features and indicated differences in plasticity between CYP3A4 and CYP3A5 that favor alternative ritonavir conformations.

A pseudogene (CYP3AP2) separates CYP3A4 from CYP3A7, and another (CYP3AP1) separates CYP3A7 from CYP3A5. The CYP3A5 gene is first in the cluster and closest to the centromere .

CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR. Ranjana Mitra, Oscar B. Goodman