Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central …

Jul 1, 2008 · In this issue, we will discuss CYP2D6?an enzyme that is involved in the metabolism of numerous drugs. CYP2D6 also is involved in the activation of some drugs, so these drugs …

Dec 24, 2024 · CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CYP2D6 include …

Sep 24, 2019 · The wikipedia article on CYP2D6 is a good resource to learn about this gene, and includes a large table of the drugs known to be metabolized by the CYP2D6 protein. In fact, …

May 12, 2023 · The CYP2D6 enzyme, found mostly in the liver and brain, is responsible for the metabolism of commonly prescribed drugs such as antidepressants, antipsychotics, beta …

Oct 7, 2024 · The CYP2D6 gene is located in chromosome 22q13.1. It comprises 9 exons, encoding for 497 amino acid residues . The gene cluster that includes CYP2D6 also contains …

Apr 7, 2024 · The CYP2D6 gene is a critical component of drug metabolism and plays a significant role in the field of pharmacogenomics. This gene is responsible for breaking down …

Oct 30, 2020 · Thus, this review will focus on describing CYP2D6 genomic variation, the functional consequences of this variation, laboratory methods to detect and analyse CYP2D6 …

Nov 15, 2003 · Computational approaches are used to predict and rationalize substrate specificity and enzymatic properties of CYP2D6. Pharmacophore modeling of ligands and protein …

HGNC Approved Gene Symbol: CYP2D6. Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38) : 22:42,126,499-42,130,810 (from NCBI) The hepatic cytochrome P450 system is …