Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids. In humans, the …

The CYP2C9 gene provides instructions for making an enzyme that is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. The CYP2C9 enzyme breaks down (metabolizes) compounds including steroid hormones and …

CYP2C9 is an enzyme that is responsible for breaking down (metabolizing) several of the drugs that are commonly used today. Some medications, such as celecoxib, warfarin, and phenytoin require CYP2C9 in order for the medication to be metabolized to forms that are not active and are more easily eliminated from the body.

CYP2C9 is the enzyme responsible for the metabolism of the S-isomer of warfarin that is principally responsible for the anticoagulant effect of the drug. The crystal structure of human CYP2C9 was described by Williams et al. [46], for both CYP2C9 in complex with warfarin and unliganded CYP2C9 (Protein Data Bank ID: 1OG2 and 1OG5, respectively).

2008年3月1日 · In thisissue, we will discuss an old standby,CYP2C9, an enzyme involved in manyclinically important drug interactions. CYP450 enzymes, found primarily inthe liver, are involved in the metabolismof most medications; the mostimportant of these enzymes areCYP1A2, CYP2C9, CYP2C19, CYP2D6,and CYP3A4.

2024年12月24日 · CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) is a Protein Coding gene. Diseases associated with CYP2C9 include Coumarin Resistance and Warfarin Sensitivity. Among its related pathways are Metapathway biotransformation Phase I and II and Clomipramine Pathway, Pharmacokinetics.

2021年9月9日 · CYP2C9 is an important drug-metabolizing enzyme. It is responsible for the clearance of up to 15-20% of clinical drugs, and CYP2C9 gene variants greatly affect the way we react to these drugs. Read on to learn more about enzyme function, genetics, and factors that increase or decrease CYP2C9 activity. What is CYP2C9?

2025年2月8日 · Title: Effects of CYP3A4 and CYP2C9 genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226. Identification and in vitro functional assessment of 10 CYP2C9 variants found in Chinese Han subjects.

2017年12月28日 · CYP2C9 substrate selectivity is detailed and, based on crystal structures for the enzyme, we describe how CYP2C9 catalyzes these reactions. Factors relevant to clinical response to CYP2C9 substrates including inhibition, induction and genetic polymorphism are discussed in detail.

2024年10月1日 · Clinical resource with information about CYP2C9, A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose., A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose., An atlas of genetic influences on human blood metabolites., Association of ...