Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. [5] In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene. [6]

Dec 24, 2024 · CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include Drug Metabolism, Poor, Cyp2c19-Related and Major Depressive Disorder . Among its related pathways are Clomipramine Pathway, Pharmacokinetics and Metapathway biotransformation Phase I and II .

Nov 1, 2007 · The importance of CYP1A2 for druginteractions has been increasing overthe past decade due to the growingnumber of drugs metabolized by thisenzyme. 1 Drugs metabolized by CYP1A2are called CYP1A2 substrates.

Aug 1, 2023 · What is CYP1A2? CYP1A2 is part of the drug-metabolizing enzyme family, known as cytochrome P450. CYP1A2 plays an important role in the metabolism of several mental health medications, including duloxetine, fluvoxamine, clozapine, olanzapine, and mirtazapine.

Oct 1, 2021 · ~ CYP1A2 is a phase I detoxification enzyme that breaks down caffeine as well as several other important toxins such as aflatoxin B1 from mold. ~CYP1A2 also plays a role in estrogen metabolism. ~ Common genetic variants in CYP1A2 influence whether you are a fast or slow metabolizer of caffeine.

Sep 9, 2021 · What is CYP1A2? CYP1A2 is an important detox enzyme that breaks down toxic chemicals, drugs, hormones, and other products of metabolism in order to eliminate them from your body. It’s found mainly in the liver [ 1 , 2 ].

CYP1A2. The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins. CYP1A2 Location- mainly in the liver, also the lungs and pancreas.

Jan 26, 2019 · CYP1A2 es una enzima importante que ayuda a descomponer las toxinas en nuestros cuerpos. También es la enzima clave responsable del metabolismo de la cafeína. Por lo tanto, las variaciones en el gen CYP1A2 tienen un gran impacto en cómo el café afectará nuestros cuerpos.

Jan 15, 2018 · The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins, which metabolize nutrients and drugs. One well known substrate of CYP1A2 is caffeine; individuals who carry one or more CYP1A2*1C alleles are "slow" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "fast" caffeine metabolizers. The same amount of ...

Jan 26, 2023 · Importance Caffeine is detoxified by cytochrome P450 1A2 (CYP1A2), and genetic variation in CYP1A2 impacts the rate of caffeine clearance. Factors that may modify the association between coffee intake and kidney disease remain unclear.