Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. [5] In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene. [6]

2021年10月1日 · ~ CYP1A2 is a phase I detoxification enzyme that breaks down caffeine as well as several other important toxins such as aflatoxin B1 from mold. ~CYP1A2 also plays a role in estrogen metabolism. ~ Common genetic variants in CYP1A2 influence whether you are a fast or slow metabolizer of caffeine.

2007年11月1日 · The importance of CYP1A2 for druginteractions has been increasing overthe past decade due to the growingnumber of drugs metabolized by thisenzyme. 1 Drugs metabolized by CYP1A2are called CYP1A2 substrates.

Given the predominant role of CYP1A2 in activation of toxic xenobiotics compared with its metabolism of prescription drugs, there are many epidemiological reports examining the role of variant CYP1A2, metabolism of procarcinogens, and cancer risk.

2023年8月1日 · What is CYP1A2? CYP1A2 is part of the drug-metabolizing enzyme family, known as cytochrome P450. CYP1A2 plays an important role in the metabolism of several mental health medications, including duloxetine, fluvoxamine, clozapine, olanzapine, and mirtazapine.

2024年12月24日 · CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include Drug Metabolism, Poor, Cyp2c19-Related and Major Depressive Disorder . Among its related pathways are Clomipramine Pathway, Pharmacokinetics and Metapathway biotransformation Phase I and II .

2021年9月9日 · What is CYP1A2? CYP1A2 is an important detox enzyme that breaks down toxic chemicals, drugs, hormones, and other products of metabolism in order to eliminate them from your body. It’s found mainly in the liver [ 1 , 2 ].

CYP1A2 is the major hepatic isoform of the human CYP1A subfamily (Shimada et al., 1994). Studies suggest negligible to no detectible CYP1A2 mRNA or protein expression/activity during gestation (Hakkola et al., 1994). Postnatally, CYP1A2 is the last major CYP enzyme to fully mature (Berthou et al., 1988; Sonnier and Cresteil, 1998).

CYP1A2 gene is implicated in paranoid schizophrenia; Incubation of racemic and nonracemic methadone with CYP3A4 revealed no stereoselectivity for the transformation to EDDP, whereas no EDDP formation was observed with CYP1A2. CYP1A2 catalyzes other less important pathways, such as degradation at the amino/ethanolamino group.

2025年2月8日 · Title: CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.