Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein [5] that in humans is encoded by the CYP1A1 gene. [6] . The protein is a member of the cytochrome P450 superfamily of enzymes. [7] CYP1A1 is involved in phase I xenobiotic …

Dec 24, 2024 · CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Phimosis. Among its related pathways are Metapathway biotransformation Phase I and II and Oxidation by cytochrome P450.

Jun 16, 2009 · CYP1A1 is one of the main cytochrome P450 enzymes, examined extensively for its capacity to activate compounds with carcinogenic properties. Continuous exposure to inhalation chemicals and environmental carcinogens is thought to increase the level of CYP1A1 expression in extrahepatic tissues, through the aryl hydrocarbon receptor (AhR).

Human cytochrome P450 enzymes (CYPs) play a critical role in various biological processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and CYP1B1, are induced by aryl hydrocarbon receptors (AhRs).

Jul 17, 2013 · CYP1A1 silencing reduces proliferation and survival, at least in part, through increased phosphorylation of AMP-activated protein kinase (AMPK) and reduced phosphorylation of AKT, extracellular signal-regulated kinases (ERK)-1 and 2, and 70 kDa ribosomal protein S6 kinase (P70S6K).

Oct 17, 2024 · Results: We showed that all heart regions express CYPs capable of metabolizing arachidonic acid and ω-3 PUFAs and revealed significant differences between heart regions both in the mRNA level of genes CYP1B1, CYP2J3, and CYP1A1 and in the time course of expression changes with age.

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

Sep 20, 2021 · CYP1A1 is an important enzyme involved in the detoxification and metabolism of many substances. However, this enzyme can also activate some toxic compounds into cancer-causing agents. Read on to find out more about CYP1A1, its genetics, and the natural substances that can increase or decrease CYP1A1 activity. What is CYP1A1?

May 4, 2020 · In this study, we identified CYP1A1 as a critical regulator of inflammatory responses and phagocytosis in sepsis and described two novel CYP1A1-invovled signalling pathways, CYP1A1–12(S)HETE−JNK − AP-1 and CYP1A1-SR-A, that may be promising targets for treating sepsis or other inflammatory diseases.