2024年12月24日 · CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Phimosis. Among its related pathways are Metapathway biotransformation Phase I and II and Oxidation by cytochrome P450.

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP1A1, an enzyme of the cytochrome P450 superfamily, is the most important xenobiotic-metabolizing enzyme of the placenta for which relevant inducible activity has been demonstrated throughout pregnancy.

2018年7月1日 · The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons, converting these chemicals into very potent human carcinogens. CYP1A1 expression is mainly ...

2021年9月9日 · CYP1A1 is an important enzyme involved in the detoxification and metabolism of many substances. However, this enzyme can also activate some toxic compounds into cancer-causing agents. Read on to find out more about CYP1A1, its genetics, and the natural substances that can increase or decrease CYP1A1 activity. What is CYP1A1?

CYP1A1*2A (SNP ID: rs4646903), also known as Mspl, has T–C mutation at 3801. CYP1A1*2A is reported to be positively correlated with the risk or incidence of a series of cancers, including esophageal, oral, laryngeal, prostate, cervical, bladder, and lung cancers .

2009年6月16日 · CYP1A1 is one of the main cytochrome P450 enzymes, examined extensively for its capacity to activate compounds with carcinogenic properties. Continuous exposure to inhalation chemicals and environmental carcinogens is thought to increase the level of CYP1A1 expression in extrahepatic tissues, through the aryl hydrocarbon receptor (AhR).

2024年11月14日 · This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

Human cytochrome P450 enzymes (CYPs) play a critical role in various biological processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and CYP1B1, are induced by aryl hydrocarbon receptors (AhRs).

We have developed two transgenic mouse lines. One mouse strain (CYPLucR) carries a functional human CYP1A1 promoter (–1612 to +293)-luciferase reporter gene, and the other strain (CYP1A1N) expresses CYP1A1 under control of the full-length human CYP1A1 gene and 9 kb of flanking regulatory DNA.