For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation.

Table of Substrates, Inhibitors and Inducers (including: CYP Enzymes, Clinical index drugs, transporters, and examples of clinical substrates, inhibitors, and inducers).

This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes.

Nov 8, 2022 · This article provides a summary of cytochrome P450 enzyme inducers and inhibitors as well as the relevance of genetic polymorphisms which influence metabolic pathways.

Jun 24, 2024 · Table 2 provides definitions of substrates, inhibitors, and inducers for CYP-based metabolism and Table 3 provides definitions of inhibitors and substrates for drug transporter systems.

Apr 24, 2023 · The role of cytochrome P450 (CYP) has been vastly studied for years regarding its influence in drug therapy. Predominantly operating within hepatocytes, their principal function is to metabolize hosts of xenobiotics and clearance of potentially toxic compounds.

This review presents a comprehensive update on the inhibitors and inducers of the specific CYP enzymes in humans. The focus is on the more recent human in vitro and in vivo findings since the publication of our previous review on this topic in 2008.

Oct 27, 2020 · The inhibition and induction of CYPs are major mechanisms causing pharmacokinetic drug–drug interactions. This review presents a comprehensive update on the inhibitors and inducers of the specific CYP enzymes in humans.

CYP3A4 substrates, inhibitors, and inducers commonly used in HCT (non-limitative list) (Lexicomp drug interactions 2023, MedicinesComplete 2023, Stockley’s Interactions Checker)

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis.