2023年7月4日 · 01介绍趋化因子超家族. 01. 趋化因子 是一类结构相似，分子量约8~10kDa的小分子分泌性蛋白，在稳态和炎症状态下引导细胞迁移。 趋化因子作为细胞迁移的主要调节因子，对基本的生命过程至关重要，包括生命早期的胚胎发育、免疫监视、宿主防御和伤口修复，以及随年龄而来的疾病[1,2]。

cxcr4作为具有代表性的g蛋白耦联受体（gpcr）一员，在介导肿瘤定向迁移、侵袭和转移中发挥着重要的作用，多项cxcr4开发药物在临床治疗中表现出巨大的潜力，这些药物将为 肿瘤免疫治疗 开辟一条新的途径。

In myocardial infarction (MI), coronary arteries get obstructed, and must regenerate to support continued heart function. A unique CXCR4/CXCL12-dependent process termed “artery reassembly” allows the formation of an alternative (collateral) artery network to bypass obstructed or severed coronary arteries . In the mouse, within a few days ...

2024年9月23日 · Here, we use cryo-electron microscopy to investigate various modes of human CXCR4 regulation. CXCL12 activates CXCR4 by inserting its N terminus deep into the CXCR4 orthosteric pocket.

2015年5月11日 · In this article, we review our current understanding of the CXCL12/CXCR4 axis in cancer tumorigenesis and progression and discuss its therapeutic implications.

2016年2月18日 · Cytokine CXCL12 (also known as stromal-derived factor 1α) and its receptor CXCR4 represent the most promising actionable targets for this strategy. Both are overexpressed in various cancer types, and this aberrant expression strongly promotes proliferation, migration and invasion through multiple signal pathways.

2024年9月13日 · Here, the authors study the binding and interaction between CXCR4 with CXCL12 and hBD-3 in different forms, and find that both ligands can bind with CXCR4 at the same site, and analogs of...

2024年8月27日 · Analysis of the structure identified key amino acid residues at the CXCR4 CRSs for CXCL12 binding, receptor activation, and TM signaling. By combining functional assays with site-directed mutagenesis of CXCR4 and molecular dynamics (MD) simulations, we further verified the interactions between CXCR4 and CXCL12.

CXCL12/CXCR4 antagonists have been developed and validated, which have shown promising anti-cancer activities in several tumor cell types. Five major classes of CXCR4 antagonists have been identified: (1) small modified peptides; (2) small-molecules; (3) antibodies to CXCR4; (4) modified agonists and antagonists for CXCL12; (5) microRNAs.

2020年11月1日 · The role of the CXCR4/CXCR7-CXCL12 axis in cardiac remodeling was investigated ex vivo showing that CXCL12 attracted CXCR4- and CXCR7-positive cardiac stem cells to the site of myocardial injury where cardiac remodeling was triggered through activation of the AKT and ERK pathways [116, 117].