Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2).

Dec 24, 2024 · CXCL2 (C-X-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CXCL2 include Peritonitis and Keratitis . Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling .

Jun 13, 2013 · Mast cells and macrophages both make CXCL1 and CXCL2. Neutrophil recruitment is an important early step in controlling tissue infections or injury. Here, we report that this influx depends on both tissue-resident mast cells and macrophages.

Jul 8, 2020 · Recent results outline differential roles among ELR + -CXC chemokines in neutrophil extravasation and migration. CXCL2 is almost exclusively produced by neutrophils and, in addition to CXCR1 and CXCR2, it binds the atypical chemokine receptor ACKR1.

Sep 1, 2013 · CXCL2 and CXCL3 treatment activates ERK1/2 and p38 MAPK, but not PI3K, pathways in ASMCs. Whole-cell lysates from ASMCs stimulated with 4 ng/ml CXCL2 or CXCL3 for 0, 5, 15, 30, 45, and 60 min were used in Western blot.

The CXCL2 (C-X-C motif chemokine ligand 2) is a protein-coding gene located on chromosome 4. CXCL2, a small cytokine belonging to the CXC chemokine family, is also known as macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta), and Gro oncogene-2 (Gro-2).

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

Oct 15, 2021 · By regulating CXCL2 in Raw264.7 macrophages, we found that CXCL2 on macrophage EVs recruited neutrophils in vitro and in vivo. The CXCL2 EVs activated the CXCR2/PKC/NOX4 pathway and induced tissue damage.

Nov 27, 2023 · The results showed that CXCL2 was positively correlated with immune scores, macrophages and other immune cell scores. Twenty CXCL2-related genes were predicted for enrichment analysis, and immune-related pathways such as immune cell chemotaxis were important functional categories.

4 days ago · CXCL2 is a common chemotactic cytokine secreted by various cells, such as monocytes and macrophages [32, 33]; and it has been reported play the critical role in driving cancer progression [34, 35]. Since the expression of CXCL2 is abnormally elevated in CRC tissue, it is considered as a putative prognostic biomarker for CRC [36,37,38].