2024年12月24日 · CX3CR1 (C-X3-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CX3CR1 include Macular Degeneration, Age-Related, 12 and Human Immunodeficiency Virus Type 1. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Chemokine (C-X3-C motif) ligand 1 (CX3CL1, also known as fractalkine) and its receptor chemokine (C-X3-C motif) receptor 1 (CX3CR1) are widely expressed in immune cells and non-immune cells throughout organisms.

2021年3月3日 · Here, we investigate CX3C chemokine receptor 1 (CX3CR1), a marker of T-cell differentiation, as a predictive correlate of response to ICI therapy.

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration.

2016年12月20日 · Gerlach et al. (2016) demonstrate that CX3CR1 identifies three distinct CD8+ effector and memory T cell (Tmem) subsets. CX3CR1 correlated with the degree of effector differentiation. Surprisingly, a newly identified CX3CR1int Tmem population, not effector memory cells (CX3CR1hi), was the predominant subset that surveyed non-lymphoid tissues.

2019年7月1日 · We show Cx3CR1 eGFP-hi macrophages in skin wounds are derived from long-term tissue-resident macrophages and predominantly exhibit an alternative activation state, whereas cells expressing low-intermediate Cx3CR1 eGFP are derived from the BM, contribute to both early and later stages of wound healing, and show both classical and alternative ...

CX3CR1 is a potential biomarker of immune microenvironment and prognosis in epithelial ovarian cancer. Validating Fractalkine receptor as a target and identifying candidates for drug discovery against type 2 diabetes. Obesity-related Plasma CXCL10 Drives CX3CR1-dependent Monocytic Secretion of Macrophage Migration Inhibitory Factor.

It is evident that the CX3CL1-CX3CR1 axis is key in leucocyte trafficking throughout the body and immune cell survival in certain circumstances. CX3CR1 is also expressed by microglia in the brain and CX3CL1-CX3CR1 is of importance in neurodevelopment and inflammatory disease of the central nervous system (24, 25). Certain cells of mesenchymal ...

2023年3月21日 · CX3CR1 is established—along with its ligand CX3CL1 (fractalkine)—as driving migration, increasing responsiveness to chemo-attractants, promoting interferon-gamma (IFNγ) expression, and activating cytotoxic T cells. 49, 50, 51 Moreover, while CX3CR1 + CD4 + cells were also reduced in the tumor, this reduction was not as striking as CX3CR1 ...

2022年6月29日 · As the only member of the CX3C chemokine receptor subfamily, CX3CR1 binds to its sole endogenous ligand CX3CL1, which shows notable potential as a therapeutic target in atherosclerosis, cancer, and...