Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

2024年12月24日 · CUL1 (Cullin 1) is a Protein Coding gene. Diseases associated with CUL1 include Vaccinia and Uv-Sensitive Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Toll Like Receptor 3 (TLR3) Cascade. Gene Ontology (GO) annotations related to …

CUL1 也被称为卡林，是人类的从卡林家族发现的蛋白质。 这个蛋白在 蛋白质降解 和蛋白质泛素化中起着重要的作用。 这是SCF（SKP1 CUL1- F-box蛋白的）E3 泛素连接酶 复合物的一个重要组成部分，其介导的泛素化蛋白参与细胞周期进程，信号转导和转录。 在SCF复合体中，它作为一个刚性的骨架，组织SKP1-F-box蛋白，RBX1亚基。 可能对泛素结合酶具有催化作用。 这种蛋白是CUL1，RBX1，SKP1，SKP2的SCF复合体的一部分。 还是RNF7、TIP120A / CAND1 …

The SKP1‐CUL1‐F‐box (SCF) E3 ubiquitin ligase, a member of the Cullin‐RING E3 ubiquitin ligase (CRL) family, plays a crucial role in mediating protein ubiquitination and subsequent 26S proteasome degradation during normal cellular metabolism. Notably, SCF is intricately linked to the pathogenesis of various diseases, including malignant tumors.

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane.

2002年4月18日 · Cul1 serves as a rigid scaffold that organizes the Skp1–F box Skp2 and Rbx1 subunits, holding them over 100 Å apart. The structure suggests that Cul1 may contribute to catalysis through the ...

2020年8月18日 · When analyzing chromatin affinity of individual cullins, we discovered that CUL1 preferentially associated with active promoter sequences and co-localized with 23% of all DNA-associated protein...

2024年12月10日 · Title: Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.

In this paper, we report that the highly conserved cullin C-terminal sequence and binding with ROC1 are both required for efficient nuclear accumulation of cullin. Blocking of CUL1 nuclear localization reduced its NEDD8 modification, resulting in a significant loss of IκBα ubiquitin ligase activity of CUL1 both in vitro and in vivo.

Here, we discover that Cullin1 (CUL1), a key component of the Skp1-Cullin1-F-box E3 ligase, plays a critical role in controlling the NLRP3 inflammasome. CUL1 represses inflammasome assembly in cultured cells, suppresses NLRP3 function in human monocytic cell line macrophages, and attenuates inflammatory responses in mouse model.