转录阻抑物CTCF，也被称为11锌指蛋白或CCCTC结合因子，是由人类CTCF基因编码的转录因子 [1][2]。 CTCF参与多个细胞进程，包括转录调控、绝缘子活性调控、V (D)J重组、染色质结构 …

Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [5][6] CTCF is involved in …

CTCF（CCCTC binding factor），是CTCF基因编码的转录因子 [1]，与绝缘子的活性相关。 CTCF蛋白在印记调控区域（imprinting control region，ICR）和分化甲基化区 …

Dec 24, 2024 · CTCF (CCCTC-Binding Factor) is a Protein Coding gene. Diseases associated with CTCF include Intellectual Developmental Disorder, Autosomal Dominant 21 and Ctcf …

Jun 5, 2015 · CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an …

Mar 11, 2014 · CTCF-mediated chromatin loops regulate diverse nuclear processes, including V (D)J recombination, enhancer–promoter interactions, transcriptional pausing and alternative …

CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. It can attract many other transcription factors to chromatin, including tissue-specific …

近年来提出的 loop extrusion模型 也认为CTCF和 cohesin 的协调作用是loop形成的普遍机理。 然而，虽然有了假设，人们却 一直不清楚CTCF是如何作用于染色质，并导致复杂结构的形成。 …

Feb 28, 2025 · CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis …

Mar 3, 2025 · Three-dimensional genome organization orchestrates recombination and transcription of immunoglobulin heavy chain (Igh) genes. The structure of wild-type (WT) …