CRM197, a nontoxic mutation of diphtheria toxin (DT), can be taken up by BCECs via binding the receptor of the precursor of heparin-binding epidermal growth factor-like growth factor (HB …

2016年2月4日 · One of the most widely used and highly effective carrier protein is Cross-Reactive-Material-197 (CRM 197), a mutant version of the diphtheria toxin, where the single …

2021年12月30日 · CRM197，即白喉毒素无毒突变蛋白，一个陌生的名字，但事实上，CRM197是一种广泛应用于疫苗研发领域的载体，问世数十年来，已保护数千万儿童免受多种疾病的侵害 …

Recombinant CRM197 is a nontoxigenic diphtheria toxin isolated from the fermentation culture supernatant of Corynebacterium diphtheriae C7(β197) tox-negative and purified using …

CRM 197, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines against Streptococcus pneumoniae, …

2022年10月1日 · This paper gives an overview of conjugate glycovaccines which contain recombinant diphtheria toxoid CRM197 as a carrier protein. A special focus is given to …

CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein …

2012年1月4日 · Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally …

2022年10月1日 · Covalent coupling of glycan antigens with CRM197 is used both in the development and manufacturing of vaccine preparation and in routine evaluation of …

Cross-reacting material 197 is a nontoxic mutant of diphtheria toxoid with clinical applications. CRM197 is a common carrier for polysaccharide vaccines against various pathogens. This …