Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

Mar 10, 2017 · Here, we show crystal structures of CRM1 bound to eight additional NESs which reveal diverse conformations that range from loop-like to all-helix, which occupy different …

Jun 27, 2017 · Chromosome Region Maintenance1 (CRM1), a nuclear transporter protein, mediates the export of around 220 proteins and mRNA across the nuclear envelope (NE), and …

Dec 17, 2015 · CRM1, also called exportin 1 or Xpo1, is the most conserved nuclear export receptor (Adachi and Yanagida, 1989; Fornerod et al., 1997a; Fukuda et al., 1997; Stade et …

Jan 1, 2014 · CRM1, chromosome region maintenance 1 protein also known as exportin-1 (XPO1), mediates the export out of the nucleus of cellular proteins with a leucine-rich nuclear …

Sep 8, 2015 · Yet, proteins and other molecules can move in and out of the nucleus by passing through small pores in this nuclear membrane. To travel through these pores, larger molecules …

CRM1 (Chromosome region maintenance 1; Exportin 1; XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear protein export receptor that recognizes …

Dec 10, 2024 · CRM1 (XPO1) has been well-characterized as a shuttling receptor that mediates the export of protein and RNA cargos to the cytoplasm, and previous analyses have …

Dec 15, 2014 · The location of real NESs near protein termini and within loops or disordered regions may increase their accessibility to CRM1 or enhance their adaptability for suitable …

CRM1 inhibitors belong to a class of compounds designed to target Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1, a critical mediator of nuclear export. CRM1 …