Cytokeratin 20 (CK20) is a protein made by epithelial cells in the colon and urinary tract. It is also made by Merkle cells in the skin.

Combined analysis of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is often used for assessing the origin of metastatic cancer. To evaluate the diagnostic utility of CK7 and CK20, tissue microarrays containing 15,424 samples from 120 different tumor types and subtypes and 608 samples of 76 different …

Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene. [5] [6] [7] Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. [8]

Relative expression of CK20/CK7 is an approved diagnostic tool to help determine site of origin in metastatic carcinomas. CK20 is specific for colonic, urothelial and Merckel cell carcinoma. On the other hand, CK7 is characteristic of glandular malignancies originating from breast, respiratory tract, biliary tract and Mullarian epithelium.

For this purpose immunohistochemical analyses are often required, utilizing antibodies directed against CK8-18, Hep-Par1, glypican 3, CK7, CK19, CK20. Here we report a case of a 65-year-old man who presented with a clinical picture of decompensated cirrhosis.

All cases of mucinous colon adenocarcinoma showed staining for CK20, while only one out of 11 (9%) was positive for CK7 (ref). Therefore, both CK7 and CK20 staining of lung lesions should be obtained and can help to differentiate between a primary lung vs metastatic colon adenocarcinoma.

2009年2月2日 · The first objective is to evaluate (a) the sensitivity of preoperation CK20 pCTCs in colorectal cancer and colorectal adenoma detection, (b) the origin of those CK20 pCTCs, and (c) the prognostic potential of preoperation CK20 pCTCs. The results showed that the overall detection rate in colorectal cancer is only 62% and detailed analysis ...

Cytokeratin 20 (CK20) is a low-molecular-weight cytokeratin (CK) that shows restricted expression in the gastrointestinal epithelium, urothelium, and Merkel cell.

2017年1月5日 · Cytokeratin 20, abbreviated CK20, is a commonly used immunostain. It is also known as keratin 20.

Cytokeratin 20 (CK20) is a low-molecular-weight cytokeratin, which is expressed in normal glands as well as tumors of the gastrointestinal (GI) epithelium, urothelium, and skin stem cells that give rise to Merkel cell carcinomas.