CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator. [5] Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and …

Dec 24, 2024 · CIITA (Class II Major Histocompatibility Complex Transactivator) is a Protein Coding gene. Diseases associated with CIITA include Mhc Class Ii Deficiency 1 and Mhc Class Ii Deficiency. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

Mar 4, 2025 · Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion.

The CIITA gene provides instructions for making a protein that primarily helps control the activity (transcription) of genes called major histocompatibility complex (MHC) class II genes. Learn about this gene and related health conditions.

Dec 20, 2013 · Class II transactivator (CIITA) is a transcriptional coactivator that regulates γ-interferon-activated transcription of Major Histocompatibility Complex (MHC) class I and II genes.

Oct 1, 2023 · In this review, we will focus on the MHC class II transactivator (CIITA), the master regulator of MHC class II (MHC-II) gene expression and the founding member of NLR.

In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding member of the mammalian nucleotide-binding and ...

Mar 2, 2011 · Here we show a highly expressed gene fusion involving the major histocompatibility complex (MHC) class II transactivator CIITA (MHC2TA) in KM-H2 cells.

CIITA is a highly regulated transactivator that governs all spatial, temporal, and quantitative aspects of MHC-II expression. It has been proposed to act as a non-DNA-binding transcriptional coactivator, but evidence that it actually functions at the level of MHC-II promoters was lacking.

Nov 24, 2020 · CIITA (class II major histocompatibility complex transactivator) upregulates the CD74p41 isoform, which inhibits cathepsins and prevents genome release into the cytoplasm, instead redirecting the...