Jan 1, 2024 · The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying mannose …

Dec 11, 2009 · The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR), which contains multiple mannose 6-phosphate (Man-6-P) binding sites that map to domains 3, 5, and …

Mar 1, 2003 · ;Mannose 6-phosphate (M6P) receptors (the CD-MPR and CI-MPR) are type-I integral membrane glycoproteins that constitute the family of p-type lectins. They bind to M6P …

In this report, we describe the endocytic trafficking and steady-state localization of a chimeric form of the CI-MPR containing the ecto-domain of the bovine CI-MPR and the murine …

Sep 9, 2020 · Clinically, endogenous CI-MPR delivers infused recombinant enzymes to lysosomes in the treatment of lysosomal storage diseases.

The multifunctional 300 kDa mannose 6-phosphate receptor (MPR300/CI-MPR) is a type I transmembrane glycoprotein that contains two distinct M6P binding sites in repeating …

The 300 kDa cation-independent M6P receptor (CI-MPR) mediates ligand internalization and trafficking to the endolysosomal compartments. Because of its endocytotic nature, it has been …

Nov 6, 2024 · The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in …

Sep 10, 2004 · The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46-kDa cation-dependent MPR (CD-MPR) are type I integral membrane glycoproteins that …

Oct 10, 2016 · The two P-type lectins, the 46 kDa cation-dependent mannose 6-phosphate (Man-6-P) receptor (CD-MPR) and the 300 kDa cation-independent Man-6-P receptor (CI-MPR), are …

Oct 10, 2007 · The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46 kDa cation-dependent MPR (CD-MPR) are key components of the lysosomal enzyme …

The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR), which contains multiple mannose 6-phosphate (Man-6-P) binding sites that map to domains 3, 5, and 9 within …

Sep 14, 2006 · We report a CK2‐activated phosphorylation cascade controlling PACS‐1‐ and GGA3‐mediated CI‐MPR sorting. PACS‐1 links GGA3 to CK2, forming a multimeric complex …

Apr 12, 2004 · The cation-independent mannose 6-phosphate receptor (CI-MPR) mediates sorting of lysosomal hydrolase precursors from the TGN to endosomes. After releasing the …

Dec 1, 2020 · The cation-independent mannose 6-phosphate (M6P)/Insulin-like growth factor-2 receptor (CI-MPR/IGF2R) is an ∼300 kDa transmembrane protein responsible for trafficking …

Results: PLEK2 and IFI6, highly expressed in mesenchymal phenotype, were identified as novel biomarkers relating to non-MPR in neoadjuvant immunotherapy cohort [PLEK2 high, OR (95% …

1 day ago · The primary endpoint, percent change from baseline in lumbar spine bone mineral density at week 12, was achieved in both full analysis and per-protocol sets (least squares …

In our study, we explored the potential value of 18 F-FDG PET/CT in predicting MPR of neoadjuvant immunochemotherapy. MPR is a commonly used alternative predictor of survival …

Oct 31, 2003 · In this report, we describe the endocytic trafficking and steady-state localization of a chimeric form of the CI-MPR containing the ecto-domain of the bovine CI-MPR and the …

Mar 5, 2025 · Between weeks 64 and 76, more patients treated with obinutuzumab achieved CRR with a prednisone dose of 7.5mg per day or lower compared with those who received placebo …