Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene. [5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

2024年12月24日 · CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit) is a Protein Coding gene. Diseases associated with CHRNA7 include Adenylosuccinase Deficiency and Chromosome 15Q13.3 Deletion Syndrome. Among its related pathways are Transmission across Chemical Synapses and Postsynaptic nicotinic acetylcholine receptors.

2025年3月8日 · Knockdown of cholinergic receptor, nicotinic, alpha 7 (CHRNA7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1: PubMed

烟碱型乙酰胆碱受体 (nAChRs) 是配体门控离子通道超家族的成员，可介导突触处的快速信号传输。 nAChRs 被认为是由同源亚基组成的异源五聚体。 每个亚基的拟议结构是一个保守的 N 末端细胞外结构域，然后是三个保守的跨膜结构域、一个可变的细胞质环、第四个保守的跨膜结构域和一个短的 C 末端细胞外区域。 由该基因编码的蛋白质形成同源寡聚通道，显示出对钙离子的显着渗透性，并且是被α-金环蛇毒素阻断并对α-金环蛇毒素高度敏感的大脑烟碱受体的主要成分。 一 …

The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery. CHRNA7 is genetically linked to multiple disorders with cognitive deficits, including schizophrenia, bipolar disorder, ADHD, epilepsy, Alzheimer's d …

The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery. CHRNA7 is genetically linked to multiple disorders with cognitive deficits, including schizophrenia, bipolar disorder, ADHD, epilepsy, Alzheimer’s disease, and Rett syndrome.

2015年9月1日 · CHRNA7 is genetically linked to multiple disorders with cognitive deficits, including schizophrenia, bipolar disorder, ADHD, epilepsy, Alzheimer's disease, and Rett syndrome. The regulation of CHRNA7 is complex; more than a dozen mechanisms are known, one of which is a partial duplication of the parent gene.

2025年2月11日 · Chrna7 knockout alleviates biliary hyperplasia and liver fibrosis in experimental cholestasis. study suggests a novel role for beta-cell alpha7nAChR that functions to maintain beta-cell survival and mass homeostasis through modulating islet cytokine and phosphatidylinositol 3-kinase-dependent signaling pathways.

2017年8月16日 · The CHRNA7 cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha-7 neuronal nicotinic subunit (90%). Elliott et al. (1996) and Groot Kormelink and Luyten (1997) also cloned the alpha-7 gene and noted differences with the sequence reported by Peng et al. (1994) .

Description: Homo sapiens cholinergic receptor nicotinic alpha 7 subunit (CHRNA7), transcript variant 1, mRNA. (from RefSeq NM_000746) RefSeq Summary (NM_000746): The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses.