- Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis, and carcinogenesis.pubmed.ncbi.nlm.nih.gov/38003338/
Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and …
Nov 1, 2019 · Stimulation of macrophage with recombinant CHI3L1 activated MAPK signaling cascade and induced transition to M2, while siRNA knockdown of IL13-Ra2 abolished it. In an in vitro coculture system, supernatants from CHI3L1-stimulated M2 macrophages and promoted …
- Author: Nana Xu, Qiyu Bo, Rong Shao, Jian Liang, Yuanqi Zhai, Shiqi Yang, Fenghua Wang, Xiaodong Sun
- Publish Year: 2019
See results only from pubmed.ncbi.nlm.nih.govPotential Roles and Future Pe…
Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is …
CHI3L1 (Chitinase 3 Like 1) u…
The analysis of immunological signatures and CHI3L1 expression indicated that …
Chitinase-3-like 1 protein co…
Chitinase-3-like 1 protein complexes modulate macrophage-mediated …
M2a Macrophage-Secreted C…
Exposure to recombinant CHI3L1 promoted an extracellular matrix metabolic …
Significance of chitinase-3-like protein 1 in the pathogenesis of ...
Jan 4, 2024 · Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis.
Chitinase-3 like-protein-1 function and its role in diseases
Sep 14, 2020 · CHI3L1 is synthesized and secreted by a multitude of cells including macrophages, neutrophils, synoviocytes, chondrocytes, fibroblast-like cells, smooth muscle …
- Author: Ting Zhao, Zhongping Su, Yingchang Li, Xiaoren Zhang, Qiang You, Qiang You
- Publish Year: 2020
Potential Roles and Future Perspectives of Chitinase 3 …
Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis, and carcinogenesis.
CHI3L1 (Chitinase 3 Like 1) upregulation is associated with …
The analysis of immunological signatures and CHI3L1 expression indicated that CHI3L1 level was highly correlated with increased expression of macrophage signature genes in esophageal …
Chitinase-3-like 1 protein complexes modulate macrophage
Aug 16, 2021 · Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma J Clin Invest . 2021 Aug 16;131(16):e147552. doi: …
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M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix …
Jun 8, 2021 · Exposure to recombinant CHI3L1 promoted an extracellular matrix metabolic imbalance in NP cells via the IL-13Rα2 receptor, along with activation of the ERK and JNK …
Tumor-recruited M2 macrophages promote gastric and breast …
M2 macrophage-secreted CHI3L1 promoted the metastasis of gastric and breast cancer cells in vitro and in vivo. The CHI3L1 protein functioned by interacting with interleukin-13 receptor α2 …
Chitinase 3-like 1 promotes macrophage recruitment …
Nov 7, 2011 · By utilizing transwell migration and tube-formation assays, overexpression of CHI3L1 in SW480 cells (human colon cancer cells) enhanced the migration of THP-1 cells (human macrophage cells) and...
Urine proteomics-based analysis identifies CHI3L1 as an immune …
4 days ago · Furthermore, our investigation found a significant correlation between CHI3L1 expression in BCa and M2 macrophage markers, including CD163, MRC1, MS4A4A, and …
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