Dec 24, 2024 · CENPF (Centromere Protein F) is a Protein Coding gene. Diseases associated with CENPF include Stromme Syndrome and Corpus Callosum, Agenesis Of. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Separation of Sister Chromatids.

Jan 5, 2025 · Centromere protein F is identified as a novel therapeutic target by genomics profile and contributing to the progression of pancreatic cancer. Chen H, et al. Genomics, 2021 Jan. PMID 33166601. Biallelic variants in CENPF causing a …

As a cell cycle-related nuclear antigen, the Centromeric protein F (CENPF) is expressed at low levels in G0/G1 cells and accumulates in the nuclear matrix in the S-phase, with the highest expression level in G2/M cells 26.

As confirmed by the Tumor Immune Estimation Resource, we found highly expressed centromere protein F (CENPF) in SKCM and its metastases. Immunostaining of human melanoma tissues demonstrated high CENPF expression.

Jan 31, 2023 · CENPF (centromere protein) is a key regulator of cell cycle progression, but its role in TNBC chemotherapy resistance remains unclear. Here, we found that CENPF, which is highly expressed in...

CENPF affects spindle assembly and chromosomal segregation, while p53 is a tumor—suppressor gene. Their dysregulation may interact and impact glioma development. Our research aims to uncover the underlying molecular mechanisms, offering new perspectives for glioma diagnosis and treatment.

The CENPF gene encodes a protein that is dynamically expressed throughout the cell cycle and is associated with the kinetochore and mitotic spindles (summary by Waters et al., 2015). Rattner et al. (1993) identified a human kinetochore protein with a …

Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways. CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle.

Dec 10, 2024 · CENPF as an independent prognostic and metastasis biomarker corresponding to CD4+ memory T cells in cutaneous melanoma. Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways.

Centromeric proteins (CENPs) family are involved in centromere formation and kinetochore organization during mitosis and play an important role in cancers. Here, we analyzed all CENPs in a panel of PC tissues and non-tumor tissues by genomics profile.