Centromere protein F is a protein that in humans is encoded by the CENPF gene. [5][6][7] It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia. [8][9]

2024年12月24日 · CENPF (Centromere Protein F) is a Protein Coding gene. Diseases associated with CENPF include Stromme Syndrome and Corpus Callosum, Agenesis Of. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Separation of Sister Chromatids.

2025年3月5日 · High CENPF expression in cancer cells might be an important event in early-stage LUAD progression. We performed scRNA-seq of clinical samples from three progressive pathological stages (AIS: n = 3 ...

2025年1月5日 · Centromere protein F is identified as a novel therapeutic target by genomics profile and contributing to the progression of pancreatic cancer. Chen H, et al. Genomics, 2021 Jan. PMID 33166601. Biallelic variants in CENPF causing a …

The CENPF gene encodes a protein that is dynamically expressed throughout the cell cycle and is associated with the kinetochore and mitotic spindles (summary by Waters et al., 2015). Rattner et al. (1993) identified a human kinetochore protein with a …

As a cell cycle-related nuclear antigen, the Centromeric protein F (CENPF) is expressed at low levels in G0/G1 cells and accumulates in the nuclear matrix in the S-phase, with the highest expression level in G2/M cells 26.

As confirmed by the Tumor Immune Estimation Resource, we found highly expressed centromere protein F (CENPF) in SKCM and its metastases. Immunostaining of human melanoma tissues demonstrated high CENPF expression.