Dec 24, 2024 · CDKN1A (Cyclin Dependent Kinase Inhibitor 1A) is a Protein Coding gene. Diseases associated with CDKN1A include Bladder Cancer and Hyperparathyroidism. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects.

Mar 31, 2022 · Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase inhibitor p21/WAF1/CIP1/CDKN1A is required for downregulation. RB-E2F...

The cell cycle inhibitor p21 (CDKN1A) is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent kinases.

Feb 20, 2025 · Title: Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response. A candidate prognostic biomarker: TFEB inhibits tumor progression via elevating CDKN1A in bladder cancer.

Nov 8, 2022 · Here, we demonstrate that tumor cell phagocytosis drives the pro-inflammatory activation of TAMs and identify a key role for the cyclin-dependent kinase inhibitor CDKN1A (p21).

Jun 15, 2007 · Cell cycle arrest in response to DNA damage involves protein stabilization and consequent upregulation of p53, which induces transcription of cyclin-dependent kinase inhibitor p21 (CDKN1A). We now show that p21 acts as a negative regulator of the cellular levels of p53. p21 knockdown by short hairpi …

p21, encoded by the gene CDKN1A, is the founding member of cyclin-dependent kinase (Cdk) inhibitors (CKI) [1], a pivotal cell cycle regulator ensuring genomic stability and often deregulated in human cancer [2, 3, 4].

Cdkn1a variant 2 increases as cells acquire senescent phenotypes in culture. Time course of (A) p21var1 and p21var2 levels and (B) p16 Ink4a and lamin B1 mRNA levels after 15 Gy irradiation. 2-way ANOVA test was applied.

In this comprehensive review, we provide an overview of the multifaceted functions of CDKN1A/p21, present clinical data pertaining to cancer patients, and delve into potential strategies for targeting CDKN1A/p21 as a therapeutic approach to cancer.

Apr 1, 2001 · CDKN1A is implicated in regulation of cell growth and cell response to DNA damage. It inhibits cell cycle progression in G1 by binding to G1 cyclin-CDK complexes and to PCNA antigen and may also induce G2 arrest.