2024年12月24日 · CDKN1A (Cyclin Dependent Kinase Inhibitor 1A) is a Protein Coding gene. Diseases associated with CDKN1A include Bladder Cancer and Hyperparathyroidism. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects.

2022年3月31日 · Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase inhibitor p21/WAF1/CIP1/CDKN1A is required for downregulation. RB-E2F...

CDKN1A specific recognition involves the direct interaction of TRIM71 NHL domain with a structural RNA stem-loop motif within the CDKN1A 3'UTR. Importantly, CDKN1A repression occurs independently of miRNA-mediated silencing.

The cell cycle inhibitor p21 (CDKN1A) is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent kinases.

2022年11月8日 · Here, we demonstrate that tumor cell phagocytosis drives the pro-inflammatory activation of TAMs and identify a key role for the cyclin-dependent kinase inhibitor CDKN1A (p21).

Cdkn1a variant 2 increases as cells acquire senescent phenotypes in culture. Time course of (A) p21var1 and p21var2 levels and (B) p16 Ink4a and lamin B1 mRNA levels after 15 Gy irradiation. 2-way ANOVA test was applied.

2025年2月25日 · The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse.

2024年3月15日 · CDKN1A confers radioresistance to A549 and H1650 human lung adenocarcinoma cells. CDKN1A influences radiation-induced pyroptosis in A549 cells and xenograft tumors. CDKN1A inhibits AIM2 inflammasome activation by promoting DNA repair.

Therefore, mutation in CDKN1A has the potential to serve as a candidate biomarker to predict chemotherapy responsiveness. Moreover, CDKN1A has been implicated as a prognostic marker in bladder cancer, as lower p21 expression has been associated with advanced pathologic stage, tumor grade, and lower overall survival . Further characterization of ...

2001年4月1日 · CDKN1A is implicated in regulation of cell growth and cell response to DNA damage. It inhibits cell cycle progression in G1 by binding to G1 cyclin-CDK complexes and to PCNA antigen and may also induce G2 arrest.