Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators.

2024年12月24日 · CDK9 (Cyclin Dependent Kinase 9) is a Protein Coding gene. Diseases associated with CDK9 include Osteoporosis and Cholestasis, Benign Recurrent Intrahepatic, 2. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle.

2021年5月9日 · In this review, the role of CDK9 in the pathogenesis of hematological and solid cancers will be discussed together with a comprehensive review of its discovery, structure, biological function, regulation, and the available pharmacological inhibitors currently being investigated as anticancer agents.

2024年11月5日 · Cyclin Dependent Kinase 9 (CDK9) is a global regulator of gene transcription and repression. While it is often dysregulated in hematological malignancies, inhibition of CDK9 in lymphoma and leukemia cells abrogates pro-survival gene programs and induces apoptosis.

2014年3月18日 · Subcellular fractionation and Western blot analyses demonstrated that CDK9 has a molecular mass of 43 kD and is located primarily in the nucleus. Northern blot analysis indicated that CDK9 was expressed as 2.8- and 3.2-kb mRNAs in all tissues tested, with the highest levels in liver and placenta.

2025年2月14日 · Voruciclib, an oral cyclin-dependent kinase (CDK) inhibitor targeting CDK9, indirectly decreases Mcl-1 protein expression and synergizes with venetoclax in preclinical models. This dose escalation study evaluated voruciclib in patients with previously treated hematologic malignancies.

2014年5月16日 · CDK9 is the catalytic subunit of the Positive Transcription Elongation Factor b (P-TEFb), which phosphorylates the CTD of RNAPII and negative elongation factors enabling for productive elongation after initiation. CDK9 associates with T-type cyclins and cyclin K and its activity is tightly regulated in cells at different levels.

2024年8月20日 · By targeting the fundamental processes that enable cancer cell survival, CDK9 inhibitors offer a highly attractive and sought-after cancer therapy in haematologic malignancies, particularly in...

2025年2月27日 · Background: Gastroesophageal cancer (GEAC) remains a major health burden and urgently needs novel therapeutic targets. The inhibition of CDK9 activity holds the potential to be a highly effective anti-cancer therapeutic. However, the functional role of CDK9, and its potential targeting in GEAC, remain largely unknown. Objective: We aim to evaluate the …

CDK9 or cyclin-dependent kinase 9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators.