Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene. [5][6] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C associate with the mediator complex and regulate transcription by several mechanisms.

2024年12月24日 · CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities and Ebstein Anomaly.

2019年1月13日 · CDK8 and its paralog, CDK19, collectively termed ‘Mediator Kinase,’ are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner, as part of a 4-protein complex called the Mediator kinase module.

2024年3月27日 · CDK8 regulates gene expression by phosphorylating transcription factors and can control the transcription process through Mediator complex. Previous studies confirmed that CDK8 is an important oncogenic factor, making it a potential tumor biomarker and a promising target for tumor therapy.

2020年1月27日 · The CDK8 gene encodes a component of a 4-subunit kinase module, comprising CCNC and either CDK8, MED12 , and MED13 or their respective paralogs CDK19 , MED12L , and MED13L , that regulates the 'Mediator complex,' a large multisubunit assembly that regulates gene expression.

2014年6月30日 · Cdk8 (or Cdk19), along with cyclin C, Med12 and Med13, form the so-called Cdk8 module characteristic of the free Mediator form, devoid of RNAPII. The Cdk8 module responds to several intracellular signaling pathways, and it is commonly associated with repression of transcription, although it can also activate transcription [ 15 ].

2022年8月25日 · Using genetically defined models and pharmacological inhibitors, we showed that CDK8 and CDK19 function in a redundant manner to regulate intestinal lineage specification in humans and mice.

2024年4月13日 · Cyclin-dependent kinase 8 (CDK8) has emerged as a promising target for inhibiting cancer cell function, intensifying efforts towards the development of CDK8 inhibitors as potential cancer therapeutics. Mutations in CDK8, a protein kinase, are also implicated as a primary factor associated with tumor formation.

2021年3月13日 · By now, CDK8 has been found to be implicated in a wide spectrum of cancers, such as breast (human cells) , ovarian, and gastric cancer, as well as acute myeloid leukemia . Although CDK19 is less well studied than CDK8, current evidence provided that it is involved in colorectal, breast, and ovarian cancer [ 95 ], as well as in fibro- and ...

2019年12月12日 · CDK8 is a cyclin-dependent kinase that forms part of the mediator complex, and modulates the transcriptional output from distinct transcription factors involved in oncogenic control. Overexpression of CDK8 has been observed in various cancers, representing a potential target for developing novel CDK8 inhibitors in cancer therapeutics.