Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene. [5][6] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) …

2024年12月24日 · CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Intellectual Developmental Disorder With Hypotonia And …

2019年1月13日 · CDK8 and its paralog, CDK19, collectively termed ‘Mediator Kinase,’ are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and …

2024年3月27日 · CDK8 regulates gene expression by phosphorylating transcription factors and can control the transcription process through Mediator complex. Previous studies confirmed …

2020年1月27日 · The CDK8 gene encodes a component of a 4-subunit kinase module, comprising CCNC and either CDK8, MED12 , and MED13 or their respective paralogs CDK19 …

2014年6月30日 · Cdk8 (or Cdk19), along with cyclin C, Med12 and Med13, form the so-called Cdk8 module characteristic of the free Mediator form, devoid of RNAPII. The Cdk8 module …

2022年8月25日 · Using genetically defined models and pharmacological inhibitors, we showed that CDK8 and CDK19 function in a redundant manner to regulate intestinal lineage …

2024年4月13日 · Cyclin-dependent kinase 8 (CDK8) has emerged as a promising target for inhibiting cancer cell function, intensifying efforts towards the development of CDK8 inhibitors …

2021年3月13日 · By now, CDK8 has been found to be implicated in a wide spectrum of cancers, such as breast (human cells) , ovarian, and gastric cancer, as well as acute myeloid leukemia . …

2019年12月12日 · CDK8 is a cyclin-dependent kinase that forms part of the mediator complex, and modulates the transcriptional output from distinct transcription factors involved in …