Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene. [5] [6] It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. [7] The protein encoded by this gene is a member of the cyclin-dependent kinase, (CDK) family, which includes CDK4. [8]

2024年12月24日 · CDK6 (Cyclin Dependent Kinase 6) is a Protein Coding gene. Diseases associated with CDK6 include Microcephaly 12, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly.

2023年4月14日 · CDK4/6 inhibitors are a class of drugs that target particular enzymes, called CDK4 and CDK6. CDK stands for cyclin-dependent kinase, and it is an enzyme that is important for cell division. CDK4/6 inhibitors interrupt signals that stimulate the proliferation of malignant (cancerous) cells.

研究表明，肿瘤细胞中，该通路失调频繁出现，导致细胞持续分裂，促进肿瘤生长。 当受到有丝分裂信号刺激时，细胞周期蛋白D (cyclin D)与CDK4或者CDK6发生相互作用。 被激活的cyclin D-CDK4/6复合物磷酸化 视网膜母细胞瘤相关蛋白 (retinoblastoma-associated protein, Rb),进而使转录抑制复合物Rb-E2F解聚，释放E2F转录因子。 接着，游离的E2F激活细胞进入S期和DNA复 …

2015年1月1日 · Our findings define CDK6 as an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 in HSCs and LSCs. A cyclin-dependent kinase (CDK) is a critical regulator of cell-cycle progression, becoming activated upon binding to cyclins.

CDK4/6 inhibitors are a class of medicines used to treat certain types of metastatic breast cancer, which is cancer that has spread to other parts of the body.

CDK6, or Cyclin-Dependent Kinase 6, is a crucial protein that plays a key role in regulating the cell cycle, particularly the transition from the G1 phase to the S phase. This kinase interacts with cyclins to drive cell proliferation and is essential for the …

2024年7月11日 · In this issue of Blood, Mayer et al 1 analyze hematopoietic stem cells (HSCs) isolated from mice with mutations in the cell-cycle kinase cyclin dependent-kinase 6 (CDK6) to study how the kinase-inactivated form of CDK6 regulates …

2016年4月3日 · FDA approval of the CDK4/6 inhibitor palbociclib used with the aromatase inhibitor letrozole for breast cancer treatment highlights long-sought success. The newest findings herald clinical trials targeting other cancers.

2023年11月10日 · The roles of cyclin-dependent kinase 6 (CDK6) in various cancers, including small cell lung carcinoma (SCLC), remain unclear. Here, 111,54 multi-center samples were investigated to determine the expression, clinical significance, and underlying mechanisms of CDK6 in 34 cancers.