Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. [5] [6] The protein encoded by this gene is a …

May 20, 2022 · Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …

In dividing cells, cyclin-dependent kinase 2 (CDK2) is a major cell cycle component that controls the G1/S and S/G2 transitions.

Dec 24, 2024 · CDK2 (Cyclin Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include Breast Cancer and Endometrial Hyperplasia. Among its related …

6 days ago · Cyclin-dependent kinase 2 (CDK2) is a key target in cancer research due to its role in cell cycle progression. Inhibiting CDK2 offers therapeutic potential, particularly in cancers …

Apr 17, 2020 · Cyclin-dependent kinase 2 (CDK2) controls cell division and is central to oncogenic signaling. We used an “in situ” approach to identify CDK2 substrates within nuclei isolated …

Feb 9, 2025 · Here, the authors investigate CDK2-dependancy and response to CDK2 inhibition across different cancers, identifying markers of sensitivity and combinatorial therapeutic …

Cyclin-dependent kinase 2 (CDK2) is a protein kinase that is essential for controlling cell division and the cell cycle. CDK2 dysregulation has been linked to several cancer forms, leading to it …

May 9, 2019 · Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it …

Jun 1, 2023 · CDK2 is hyperactivated in multiple cancers and is therefore an attractive therapeutic target. Here, we use several CDK2 inhibitors in clinical development to interrogate CDK2 …