2024年12月24日 · CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome and Attention Deficit-Hyperactivity Disorder 8. Among its related pathways are Cell junction organization and Blood-Brain Barrier: Anatomy.

CDH2 belongs to the classic cadherin family of Ca2+-dependent cell adhesion molecules with a meticulously described dual role in cell adhesion and β-catenin signaling. During CNS development, CDH2 is involved in a wide range of processes including ...

Evidence of CDH2/N-cadherin expression, predictive of invasion synchronous with DCIS, may help to clarify a diagnosis and direct the course of therapy earlier in a patient's care.

2017年3月8日 · CDH2 encodes cadherin 2 (also known as N-cadherin), a protein that plays a vital role in cell adhesion, making it a biologically plausible candidate gene in ARVC pathogenesis.

2025年1月4日 · Title: The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis. N-cadherin dynamically regulates pediatric glioma cell migration in complex environments.

Here we focus on the role of the cell adhesion molecule N-cadherin (CDH2) within the malignant BM microenvironment and associated signalling pathways that may bear promise as therapeutic targets.

2015年9月30日 · Thus, Cdh2 contributes to the establishment and maintenance of FGF signaling-dependent self-renewal in mEpiSCs through stabilization of FGFR1.

CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow.

2021年10月26日 · Here we demonstrate familial ADHD caused by a missense mutation in CDH2, which encodes the adhesion protein N-cadherin, known to play a significant role in synaptogenesis; the mutation affects...

2022年9月23日 · CDH2 belongs to the classic cadherin family of Ca 2+ -dependent cell adhesion molecules with a meticulously described dual role in cell adhesion and β-catenin signaling. During CNS development, CDH2 is involved in a wide range of processes including maintenance of neuroepithelial integrity, …