Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle.

Dec 24, 2024 · CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Nocarh Syndrome. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and GPCR Pathway.

Cdc42 impairs the insulin secretion and promotes IR via suppressing the activity of PAK-1. Cdc42 can affect IR in adipose tissue by (a) interaction of CIP4 with TC10; (b) Gαq/11 participating in Cdc42 and PI3K to mediate insulin signalling to glucose transport.

Cdc42 localizes to membranes via a post-translational C-terminal geranylgeranyl lipid modification; however, it can be found as a soluble complex association with RhoGDI (Rho GDP-dissociation inhibitor), another means of regulating Cdc42’s activation.

Feb 9, 2025 · Cdc42 is a critical regulator of T cell actin dynamics, T cell receptor clustering, and cell cycle entry. Cdc42 activity in specific locations at specific times is most critical for its function in T cell activation.

Cdc42 is one of the most important members of the Rho-GTP family and it is found first in fission yeast. It plays a crucial role in regulating the cell cycle, controlling gene transcription, regulating the cytoskeleton, cell movement, and polarization.

Jun 11, 2020 · Cdc42 is a major regulator of ROS formation, degranulation as well as activation of neutrophils in a stimulus dependent manner. We reported that Cdc42 seems to be a positive regulator of LPS induced effector mechanisms while it appears to be a negative regulator of GPCR-triggered neutrophil functions.

Here, we report that missense variants in CDC42, a gene encoding a small GTPase functioning as an intracellular signaling node, underlie a clinically heterogeneous group of phenotypes characterized by variable growth dysregulation, facial dysmorphism, and neurodevelopmental, immunological, and hematological anomalies, including a phenotype ...

Jan 4, 2023 · The role of Cdc42 in T2DM pathogenesis has been confirmed by bioinformatics analysis, which has shown that the Cdc42 gene is a candidate gene involved in the development of T2DM (Zhu et al. 2020). A recent study found that Cdc42 is also involved in T2DM-associated diabetic nephropathy.

Jan 4, 2025 · Clinical resource with information about CDC42, Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients., Macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome, and available tests.