2024年12月24日 · CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Nocarh Syndrome. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and GPCR Pathway.

Cdc42 impairs the insulin secretion and promotes IR via suppressing the activity of PAK-1. Cdc42 can affect IR in adipose tissue by (a) interaction of CIP4 with TC10; (b) Gαq/11 participating in Cdc42 and PI3K to mediate insulin signalling to glucose transport.

Cdc42 localizes to membranes via a post-translational C-terminal geranylgeranyl lipid modification; however, it can be found as a soluble complex association with RhoGDI (Rho GDP-dissociation inhibitor), another means of regulating Cdc42’s activation.

2025年2月9日 · Cdc42 is a critical regulator of T cell actin dynamics, T cell receptor clustering, and cell cycle entry. Cdc42 activity in specific locations at specific times is most critical for its function in T cell activation.

Recent studies by conditional gene targeting of cdc42 in mice have revealed its tissue- and cell type-specific role and provide definitive information of the physiological signaling functions of Cdc42 in vivo.

2019年1月6日 · Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin cytoskeleton organization and membrane trafficking.

A hallmark of endothelial senescence is the persistent up-regulation of pro-inflammatory genes. We identified CDC42 signaling as a mediator of chronic inflammation associated with endothelial senescence. Inhibition of CDC42 or NF-κB signaling attenuated the sustained up-regulation of pro-inflammatory genes in senescent human endothelial cells.

Consistent with the involvement of Cdc42 in EMT-mediated cell movement, overexpression of the Cdc42 GEF, ARHGEF9, is commonly observed in hepatocellular carcinoma samples and correlates with increased Cdc42 activation, reduced E …

2020年6月11日 · Cdc42 is a major regulator of ROS formation, degranulation as well as activation of neutrophils in a stimulus dependent manner. We reported that Cdc42 seems to be a positive regulator of LPS induced effector mechanisms while it appears to be a negative regulator of GPCR-triggered neutrophil functions.

Cdc42 is particularly known for its unique role in controlling cell polarity and in modulating polarized cell functions, including the proper formation of epithelial tight and adherens junctions. 6-8 Thus, it is essential for correct morphogenesis of organs such as the heart, lungs, pancreas, and kidneys during early development. 9,10 This ...