2024年12月24日 · CD99 (CD99 Molecule (Xg Blood Group)) is a Protein Coding gene. Diseases associated with CD99 include Extraosseous Ewing Sarcoma and Lymphoblastic Lymphoma . Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation .

CD99 acts through homophilic interactions and enables homo- or heterotypic cell aggregation. CD99 can mediate diverse cellular processes such as adhesion, transendothelial migration, differentiation, and cell death, thereby affecting immune …

This review summarizes the recent progress of CD99 in cancer research and targeting therapies, especially in cancer immunotherapy, which may help researchers understand the crucial roles of CD99 in cancer development and design new therapeutic strategies.

CD99 is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, and transmembrane protein transport, and also in T-cell death by a caspase-independent pathway. It may have the ability to rearrange the actin cytoskeleton, and may also act as an oncosuppressor in osteosarcoma.

2023年8月23日 · CD99 is expressed in specific cell states of gliomas. Under hypoxia conditions, CD99 is upregulated and is associated with angiogenesis and metabolic reprogramming. Gliomas with over-expressed CD99 increases the infiltration of tumor-associated macrophages.

2019年4月2日 · CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is highly expressed by these tumors. It has been reported that CD99 can affect the migration, invasion and metastasis of tumor cells. Our results show that CD99 is also highly expressed in the tumor vasculature of most solid tumors.

CD99 is a cell surface protein with unique features and only partly defined mechanisms of action. This molecule is involved in crucial biological processes, including cell adhesion, migration, death, differentiation and diapedesis, and it influences processes associated with …

2018年2月5日 · CD99 (MIC2) is a widely expressed cell surface glycoprotein and functions as a tumor suppressor involved in downregulation of SRC family of tyrosine kinase. CD99 expression is tightly regulated...

In order to analyze the relevance of CD99 for diapedesis of myeloid cells in vivo, we used a blocking monoclonal antibody against the homologue mouse CD99. Our results demonstrate in a peritonitis model, that CD99 is necessary for extravasation of both monocytes and neutrophils.

2002年1月14日 · CD99 is a heavily O-glycosylated 32-kD type I transmembrane protein that is expressed on most hematopoietic cells. We show here that CD99 is expressed on endothelial cells and is...