Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen.

CD90 functions in inflammation and wound healing by synthesizing and releasing growth factors, cytokines and extracellular matrix components to assist in repairing damaged tissue. CD90 plays a role in cell–matrix and cell–cell adhesion between inflammatory mediators of …

CD90 is a regulator of fibroblast stiffness sensing and is physically coupled to inactive αvβ3 integrins through its RGD-like motif. CD90 alters the affinity of baseline integrins for ECM ligands and promotes pre-adhesive aggregation of integrins and membrane rafts via the glycophosphatidylinositol tether of CD90.

CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression ...

CD90 refers to a molecule that belongs to the immunoglobulin supergene family and is expressed in a subset of CD34+ cells in the bone marrow. It is also expressed in fibroblasts and other stromal cells.

2016年7月28日 · CD90 is a glycoprotein present in the MSC membranes and also in adult cells and cancer stem cells. The role of CD90 in MSCs remains unknown. Here, we sought to analyse the role that CD90 plays in the characteristic properties of in vitro expanded human MSCs.

CD90 is a surface glycoprotein called Thy-1 or Thy-1 cell surface antigen. CD90 controls vital cellular processes, including cell–cell, cell–matrix interactions, adhesion, migration, T-cell activation, and cell death.