1 day ago · CD66b signaling triggers intracellular cascades involving Src family kinases and mitogen-activated protein kinases (MAPKs), which contribute to neutrophil survival and effector functions. In acute inflammation, such as sepsis, CD66b activation enhances neutrophil responsiveness to bacterial components, leading to amplified oxidative burst activity.

Directly isolated neutrophils express very high levels of CD66b. It is also expressed by eosinophils. See supplemental figure S4H in this recent Immunity paper

The CD66b + monocytes displayed high phagocytic activity, matrix adhesion and migration, and provided costimulation for T cell proliferation and IFN-γ secretion; thus, they did not suppress T cell responses. Irrespective of clinical stage, they were identified in various cancers.

Dec 15, 2007 · CD66b (CEACAM8, CGM6, NCA-95) is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic Ag supergene family. CD66b is an activation marker for human granulocytes; however, its …

Dec 24, 2024 · CEACAM8 (CEA Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Paroxysmal Nocturnal Hemoglobinuria and Hemoglobinuria. Among its related pathways are Innate Immune System and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM6.

CD66b, a granulocyte activation marker typically found on neutrophils and eosinophils, may have predictive value in patients treated with immunotherapy.

Neutrophils express several heavily glycosylated carcinoembryonic antigen (CEA)-related glycoproteins (CD66 antigens) which have been implicated in adhesion to E-selectin and as receptors for the lectins galectin 3 and bacterial type-1 fimbriae.

CD66b is a GPI-anchored glycoprotein of the carcinoembryonic antigen (CEA) family and is located in the specific granules . It is only known to be expressed on human granulocytes and on the granulocytes of two primate species and is associated with …

Mar 15, 2016 · Cell sorting against CD11b, CD16 and CD66b allowed for the enrichment of mature neutrophils, yielding neutrophil populations with up to 99% purity. These findings suggest an ideal surface marker set for isolating mature neutrophils from humans.

CD66b is thought to play a role in the regulation of the adhesive activity of CD11/CD18 via signal transduction in neutrophils. It is strongly expressed by myelocytes, metamyelocytes, neutrophils and polymorphonuclear neutrophils. CD66b is weakly expressed by promyelocytes.