In this mini-review, we discuss some of the known and proposed mechanisms by which Tregs exert their influence in the context of immune regulation, and the contribution of mathematical modeling for these mechanistic studies.

These CD4 + CD25 + Foxp3 + Treg cells, which account for ∼10% of peripheral CD4 + T cells, are essential to the balance between pro- and anti-inflammatory responses at mucosal surfaces. There are two subsets of Treg cells, “natural” Treg (nTreg) cells and “induced” Treg (iTreg) cells.

CD4 + T cells are commonly divided into regulatory T (Treg) cells and conventional T helper (Th) cells. Th cells control adaptive immunity against pathogens and cancer by activating other effector immune cells.

2020年5月4日 · Naturally arising regulatory CD4 + T (Treg) cells, which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell subpopulation...

Treg were originally identified as a CD4 + CD25 + T cell population with the capacity to suppress an immune response. Magnetic cell separation approaches leverage the high expression of CD25 on Treg to enrich Foxp3 + cells from both humans and mice.

First, cytotoxic T-lymphocyte antigen 4 (CTLA4)–CD80/CD86 interactions induce the release of indoleamine 2,3-dioxygenase (IDO), a potent regulatory molecule, which induces the catabolism of...

Regulatory T cells (Tregs) are CD4 + T cells that are key players of immune tolerance. They are powerful suppressor cells, able to impact the function of numerous immune cells, including key effectors of inflammation such as effector T cells.

Tregs suppress activation, proliferation and cytokine production of CD4+ T cells and CD8+ T cells, and are thought to suppress B cells and dendritic cells. Tregs can produce soluble messengers which have a suppressive function, including TGF-beta, IL-10 and adenosine.

2013年11月17日 · In this mini-review, we discuss some of the known and proposed mechanisms by which Tregs exert their influence in the context of immune regulation, and the contribution of mathematical modeling for these mechanistic studies.

Memory CD4 Treg: Memory CD4 regulatory T cells (Treg) arise when Naive CD4 Tregs encounter their cognate antigen and receive further activating signals, which support differentiation. This population is delineated in scRNA-seq by the expression of ITGB1 .