CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft rejection and were also shown to induce long-term remission of autoimmune diabetes in nonobese diabetic (NOD) mice [8].

CD3 is an essential T cell co-receptorand defines T cell lineage. CD3is therefore an ideal T cell marker. This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

21 小时之前 · CD3-directed agents vary in therapeutic applications, safety profiles, and mechanisms of action. Differences in antibody affinity, isotype selection, and molecular modifications influence T-cell activation and immune modulation. Some agents induce potent T-cell activation for cytotoxic responses, while others promote immune tolerance or ...

2025年1月15日 · T-cells are a key component of the adaptive immune system, playing a role in identifying and eliminating pathogens. Their functionality is largely determined by surface proteins such as CD3, CD4, and CD8, which contribute to their ability to recognize antigens and orchestrate an immune response.

2022年3月18日 · CD3 is expressed as either TCR alpha / beta or TCR gamma / delta heterodimers, coexpressed at cell surface with the TCR complex (Immunity 2006;24:133) CD3 is first expressed in the cytoplasm of developing T cells, then as they mature it moves to the membrane ( Immunity 2006;24:133 )

CD3 is a multimeric protein complex comprising three different subunits: CD3δε, CD3γε, and CD3ζζ dimers. Homologous CD3δε and CD3γε are heterodimers with single extracellular immunoglobulin domains that interact with the TCR α and β chains and have relatively short intracellular signaling domains.

2024年6月7日 · CD3 is a pivotal component of the immune system, playing a crucial role in the activation and function of T cells. Its importance in immune signaling and regulation makes it a key target for therapeutic interventions and a valuable marker in clinical diagnostics.

2023年11月6日 · Minguet and colleagues systematically examine how individual CD3 chains of the TCR–CD3 complex can improve chimeric antigen receptor (CAR) T cell performance.

In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells). It consists of a protein complex and is composed of four distinct chains.