B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC - TCR signal between the APC and the T cell, respectively.

2002年2月1日 · Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential.

2024年2月13日 · Advances in understanding B7:CD28 pathways have ushered in a new era of immunotherapy with effective drugs to treat cancer, autoimmune diseases, infectious diseases, and transplant rejection.

Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential. The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance.

The CD28/B7 receptor/ligand system is one of the dominant costimulatory pathways. Interruption of this signaling pathway with CD28 antagonists not only results in the suppression of the immune response, but in some cases induces antigen-specific tolerance.

2023年4月17日 · The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases.

When CD28 interacts with coligand B7-2, these superantigens elicit T-cell hyperactivation. Superantigens can form this overexpression by controlling interactions between MHC-II and TCRs as well as increasing the B7-2 and CD28 costimulatory interactions.