Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene. [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ] The protein belongs to the CD28 and CTLA-4 cell-surface receptor family.

ICOS (inducible T-cell co-stimulator or CD278) is an inducible co-stimulatory member of the CD28 super-family, primarily expressed on activated CD4 cells.

Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including …

Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is expressed on antigen-presenting cells and somatic cells, including tumour cells in the tumour microenvironment.

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CD278 or ICOS (Inducible T-cell COStimulator) is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for T h 2 cells in particular. [4] [5]

The inducible co-stimulator (ICOS, CD278) is essential to the efficient development of normal and pathological immune reactions. Since ICOS-deficient mice have enhanced susceptibility to experimental allergic encephalomyelitis (EAE), we have functionally analyzed a CD4+ICOS+ population comprising 6- …

The inducible costimulator (ICOS; CD278) is a CD28 homolog and expressed in activated CD4 + and CD8 + T cells [47,48]. The ICOS ligand, known as B7–H2, CD275, or B7RP-1, is structurally related to B7 molecules but does not bind to either CD28 or CTLA-4.

The CD278 antigen, also known as ICOS molecule (inducible T-cell costimulator, Inducible Costimulator), is a disulfide-linked homodimeric T-cell surface glycoprotein of 55-60 kDa, which belongs to the CD28 and CTLA-4 cell-surface receptor family.

Feb 28, 2023 · Results: The findings revealed that ICOS expression was up regulation in most cancer types. The high expression of ICOS in tumor samples was related to the poor prognosis of UVM and LGG; The positive prognosis was boosted by the strong expression of ICOS in OV, SARC, SKCM, THYM, UCEC, and HNSC.