
IL2RA - Wikipedia
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta and the common gamma chain .
CD25 - an overview | ScienceDirect Topics
CD25 (also known as IL-2Rα receptor or the α-subunit of the IL-2 receptor) is involved in the regulation of T cell function. More specifically, it is encoded by the CD25 region on chromosome 10p15.1, is highly expressed in Tregs, and mediates IL-2 signaling which is indispensable for CD25+CD4+ Treg survival and growth [41].
CD25: A potential tumor therapeutic target - PubMed
2023年4月1日 · CD25 is the alpha-chain of the heterotrimer IL-2 receptor. CD25 is expressed on the surface of both immune and non-immune cells with different frequencies. For cancers, CD25 is expressed at high levels in many types of hematological …
IL-2 receptor - Wikipedia
IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ c, common gamma chain, or CD132); these subunits are ...
CD25 deficiency - Wikipedia
CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors.
IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune …
2018年11月1日 · In this article, we show that a fusion protein (FP) of mouse IL-2 and mouse IL-2Rα (CD25), joined by a noncleavable linker, has greater in vivo efficacy than rIL-2 at Treg expansion and control of autoimmunity.
CD25-Treg-depleting antibodies preserving IL-2 signaling on …
2020年11月9日 · Here we demonstrate potent single-agent activity of anti-CD25 antibodies optimized to deplete Treg cells, while preserving IL-2-STAT5 signaling on effector T cells and show synergy with...
CD25 as an immune regulatory molecule expressed on myeloid ... - PubMed
CD25, expressed and secreted by such DC may capture IL-2 and thereby suppress T-cell proliferation, by this means providing an accessory mechanism of DC-mediated immune suppression. We also discuss the implication of DC-derived CD25 for human disease in both cancer and chronic infection.
Role of CD25 expression on prognosis of acute myeloid leukemia…
The gene expression for interleukin-2 receptor subunit alpha (CD25/IL2RA) is frequently altered in adults with acute myeloid leukemia (AML). Increasing evidence indicates that the elevated expression of CD25 may be correlated with poor survival for ...
Phenotypic and functional characterization of human CD25
CD25 + B cells display a complete IL-2 receptor and respond to IL-2. As CD25 represents one of three chains of the IL-2 receptor, we analysed the expression of the entire IL-2 receptor (known also as CD122 and CD132) on CD25 + B cells and CD25 – B cells using unstimulated PBMC.