The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha …

CD25 (also known as IL-2Rα receptor or the α-subunit of the IL-2 receptor) is involved in the regulation of T cell function. More specifically, it is encoded by the CD25 region on …

2023年4月1日 · CD25 is the alpha-chain of the heterotrimer IL-2 receptor. CD25 is expressed on the surface of both immune and non-immune cells with different frequencies. For cancers, …

IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or …

CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The …

2018年11月1日 · In this article, we show that a fusion protein (FP) of mouse IL-2 and mouse IL-2Rα (CD25), joined by a noncleavable linker, has greater in vivo efficacy than rIL-2 at Treg …

2020年11月9日 · Here we demonstrate potent single-agent activity of anti-CD25 antibodies optimized to deplete Treg cells, while preserving IL-2-STAT5 signaling on effector T cells and …

CD25, expressed and secreted by such DC may capture IL-2 and thereby suppress T-cell proliferation, by this means providing an accessory mechanism of DC-mediated immune …

The gene expression for interleukin-2 receptor subunit alpha (CD25/IL2RA) is frequently altered in adults with acute myeloid leukemia (AML). Increasing evidence indicates that the elevated …

CD25 + B cells display a complete IL-2 receptor and respond to IL-2. As CD25 represents one of three chains of the IL-2 receptor, we analysed the expression of the entire IL-2 receptor …