Dec 24, 2024 · CD247 (CD247 Molecule) is a Protein Coding gene. Diseases associated with CD247 include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and Regulation of actin dynamics for phagocytic cup formation.

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene. [5] Some older literature mention a similar protein called "CD3 eta" in mice. It is now understood to be an isoform differing in the last exon. [6]

CD247是T细胞和自然杀伤细胞表面上的一种蛋白质，它包含一个分子质量较大的外部胞浆结构域和一个小的短胞浆尾部。 它与T细胞受体（TCR）复合物中的其他分子相互作用，形成一个完整的信号传导复合物。 主要起到信号传导的关键作用。 当T细胞受体与抗原结合时，CD247与其他CD3链（如CD3γ、CD3δ、CD3ε）以及T细胞受体α和β链相互作用，形成TCR-CD3复合物。 这一复合物通过细胞内信号传导路径激活T细胞，导致T细胞对抗原做出免疫应答。 CD247的磷酸 …

Dec 10, 2024 · Title: CD247, a Potential T Cell-Derived Disease Severity and Prognostic Biomarker in Patients With Idiopathic Pulmonary Fibrosis. A Bispecific DLL3/CD3 IgG-Like T-Cell Engaging Antibody Induces Antitumor Responses in Small Cell Lung Cancer.

CD247, which is also known as CD3ζ, CD3H, CD3Q, CD3Z, IMD25, T3Z and TCRZ, encodes CD3ζ protein, which is expressed primarily in natural killer (NK) and T cells. Since the discovery of the ζ peptide in 1986, it has been continuously investigated. In this paper, we review the composition, molecular m …

Jan 4, 2025 · CD247 is a new susceptibility locus for systemic sclerosis ASF/SF2 as a novel factor in the regulation of alternative splicing of the 3'-UTR of CD3zeta and protein expression in human T cells. Blockade of B7-H1 greatly promoted the proliferation of CD3AK cells and extended the survival time of CD3AK cells in vitro.

CD247 分子： 该基因编码的蛋白质是 T 细胞受体 zeta，它与 T 细胞受体 alpha/beta 和 gamma/delta 异二聚体以及 CD3-gamma、-delta 和 -epsilon 一起形成 T 细胞受体-CD3 复合物. zeta 链在将抗原识别与几种细胞内信号转导途径结合方面起着重要作用。

Sep 14, 2024 · CD247（Cluster of Differentiation 247），也称为T细胞受体ζ链（TCRζ chain），是一种重要的膜蛋白，参与调节T细胞的功能。 以下是CD247蛋白的基本信息和结构特征的详细介绍。

Oct 10, 2002 · Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.

研究发现CD247分子在慢性炎症、自身免疫性疾病和肿瘤发展过程中发挥重要作用。 CD247的表达和功能改变与T淋巴细胞异常活化相关,CD247基因表达水平的降低使TCR信号转导及细胞内信号转换异常,导致T淋巴细胞活化异常,进而引起免疫功能的缺失,导致慢性感染、免疫性疾病以及肿瘤的发生。 CD247在免疫系统疾病及肿瘤组. 肿瘤和自身免疫性疾病是当前的研究热点,其中免疫分子在疾病发生发展中起到了重要的作用。 研究发现CD247分子在慢性炎症、自身免疫性疾病和肿 …