CD20 is a transmembrane protein consisting of four hydrophobic transmembrane domains, one intracellular domain and two extracellular loops. There are three different forms of CD20 according to variable phosphorylation. CD20 is located on the cell surface as homo-dimeric and homo-tetrameric oligomers.

2022年4月19日 · CD20 is a CD marker—a molecule on the cell surface that can be used to identify and type a particular cell in the body. CD20 is found on the surface of B cells, but let's back up and make this easier to understand.

CD20 (cluster of differentiation 20) is a protein that is expressed on the surface of B cells, starting at the pre-B cell stage and on mature B cells in the bone marrow and in the periphery. CD20 is not expressed on hematopoietic stem cells, pro-B cells, or normal plasma cells. (1) Plasmablasts and stimulated plasma cells may express CD20.

4 天之前 · Structural differences in antigen binding influence CD20 clustering on the B-cell surface, affecting apoptotic efficiency. Types Of Anti-CD20 Monoclonal Antibodies. Anti-CD20 monoclonal antibodies are classified based on their structural composition and origin, which influence immunogenicity, efficacy, and mechanism of action.

2021年9月20日 · CD20 is a common B cell marker also called L26, membrane spanning 4 domains (MS4A1).

2019年11月13日 · While CD20 has a higher average density of surface molecules per tumor cell, CD19 expression is more homogenous and is preserved in small CD20-negative tumor subsets and after anti-CD20 targeted therapy.

1 天前 · In contrast, no patient who discontinued CD20 inhibitors cited a lack of efficacy as the reason for stopping, and 2.6% said they discontinued due to side effects or lack of tolerance.

2024年4月3日 · CD20-targeted immunotherapy encompasses diverse modalities administered at various treatment stages. Rituximab, the pioneering anti-CD20 monoclonal antibody (mAb) introduced in 1997, stands out as a well-studied, low-toxicity immunotherapy with …

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm that expresses B-cell markers CD19, CD20 (shown here), CD22, and CD79a. Surface immunoglobulins (usually IgM and IgD) are expressed with light chain restriction (lambda more commonly than kappa).

4 天之前 · The SARS-CoV2 pandemic has posed unprecedented challenges between temporary or permanent discontinuation of immunosuppressive treatment to protect patients, or disease control prioritization by not interrupting treatment. Maintenance treatment with anti-CD20 monoclonal antibodies (MoAbs) improves progression-free survival (PFS) in follicular …