CD1D is the human gene that encodes the protein CD1d, [5] a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen …

2024年12月24日 · CD1D (CD1d Molecule) is a Protein Coding gene. Diseases associated with CD1D include Follicular Dendritic Cell Sarcoma and Non-Langerhans-Cell Histiocytosis. …

CD1d is a non-polymorphic, MHC class I-like molecule, which presents phosphoand glycosphingo-lipid antigens to a subset of CD1d-restricted T cells called invariant NKT (iNKT) …

CD1d is the sole member of the group 2 CD1 molecules and is the only CD1 isoform expressed in mice, whereby protein expression is encoded by two homologous genes, Cd1d1 and Cd1d2.

2022年11月7日 · Here we uncover a function for the antigen presenting molecule CD1d in the control of lipid metabolism. We show that CD1d-deficient macrophages exhibit a metabolic …

By contrast, CD1d (group 2) molecules present lipid antigens to natural killer T (NKT) cells, a subset of which, the invariant NKT (i NKT) cells, expresses an invariant T-cell receptor...

2025年2月8日 · This review highlights the role of the CD1d antigen processing pathway and the immunopotentiating effects of the ligands that can be presented by CD1d to natural killer …

2018年2月15日 · Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d–lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to …

Here we review recent structural and biochemical studies that have shed light on the molecular details of CD1d-mediated antigen recognition by type I and II NKT cells, which are in many …

CD1d is a member of a family of CD1 glycoprotein molecules expressed on various antigen-presenting cells (APC) associated with β 2 -microglobulin [4]. Unlike MHC class I and II …