CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

CD154, also known as CD40 ligand, is a costimulatory molecule involved in humoral and adaptive immune responses upon pairing with its classical receptor, CD40. The CD154/CD40 dyad is a key participant in the pathogenesis of many autoimmune diseases, including systemic lupus erythematosus (SLE).

The interaction between CD40 and CD154 (CD40 ligand) is central in immunology, participating in CD4 + T cell priming by dendritic cells (DC), CD4 + T cell help to B cells and classical macrophage activation by CD4 + T cells.

CD154, also known as CD40 ligand, is a type 2 membrane protein expressed mainly by activated CD4+ T cells and to a lesser extent by other immune cells like CD8+ T cells, NK cells, and eosinophils. It plays a crucial role in the CD40-CD154 pathway interaction, which is essential for the induction of immune responses.

CD154 is a marker of activation expressed on T cells induced through their T-cell receptor. We analysed CD4 T-cell responses in 72 patients with chronic or resolved HCV infection (23 treatment naïve, 49 treatment experienced, including 16 who had achieved a …

CD40 ligand, a type II transmembrane protein recently renamed CD154, was originally considered restricted to activated T lymphocytes, functioning as a mediator of T cell-dependent B cell activation, proliferation, and differentiation.

CD154, also known as CD40 ligand (CD40L), previously referred to as gp39, TRAP, or TBAM [2–4], is a 39 kDa type II membrane glycoprotein of the TNF family . Located on the long arm of the X chromosome, region q26.3–q27.1, the human CD154 gene …

CD154, an inflammatory mediator also known as CD40 ligand, has been identified as a novel binding partner for some members of the integrin family. The αIIbβ3, specifically expressed on platelets, was the first integrin to be described as a receptor for CD154 after CD40.

CD154, a member of the TNF superfamily, is central to the mobilization of the adaptive immune response [77–81]. CD154 is a type 2 transmembrane protein which can be cleaved to yield a soluble form [80]. CD154 protein has been detected on platelets, CD4, CD8, and γδ-T cells.

CD40 was originally identified as a receptor on B-cells that delivers contact-dependent T helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal role played by CD40-CD40L interaction is illustrated by the defects …