
CD154 - Wikipedia
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.
Implications of CD154 and Its Receptors in the Pathogenesis and ...
CD154, also known as CD40 ligand, is a costimulatory molecule involved in humoral and adaptive immune responses upon pairing with its classical receptor, CD40. The CD154/CD40 dyad is a key participant in the pathogenesis of many autoimmune diseases, including systemic lupus erythematosus (SLE).
CD40-CD154: A perspective from type 2 immunity - PubMed
The interaction between CD40 and CD154 (CD40 ligand) is central in immunology, participating in CD4 + T cell priming by dendritic cells (DC), CD4 + T cell help to B cells and classical macrophage activation by CD4 + T cells.
CD154 - an overview | ScienceDirect Topics
CD154, also known as CD40 ligand, is a type 2 membrane protein expressed mainly by activated CD4+ T cells and to a lesser extent by other immune cells like CD8+ T cells, NK cells, and eosinophils. It plays a crucial role in the CD40-CD154 pathway interaction, which is essential for the induction of immune responses.
CD154, a marker of antigen-specific stimulation of CD4 T cells, is ...
CD154 is a marker of activation expressed on T cells induced through their T-cell receptor. We analysed CD4 T-cell responses in 72 patients with chronic or resolved HCV infection (23 treatment naïve, 49 treatment experienced, including 16 who had achieved a …
CD154 (CD40 ligand) - PubMed
CD40 ligand, a type II transmembrane protein recently renamed CD154, was originally considered restricted to activated T lymphocytes, functioning as a mediator of T cell-dependent B cell activation, proliferation, and differentiation.
CD154: An Immunoinflammatory Mediator in Systemic Lupus …
CD154, also known as CD40 ligand (CD40L), previously referred to as gp39, TRAP, or TBAM [2–4], is a 39 kDa type II membrane glycoprotein of the TNF family . Located on the long arm of the X chromosome, region q26.3–q27.1, the human CD154 gene …
Novel Functions of Integrins as Receptors of CD154: Their Role in ...
CD154, an inflammatory mediator also known as CD40 ligand, has been identified as a novel binding partner for some members of the integrin family. The αIIbβ3, specifically expressed on platelets, was the first integrin to be described as a receptor for CD154 after CD40.
CD154 - an overview | ScienceDirect Topics
CD154, a member of the TNF superfamily, is central to the mobilization of the adaptive immune response [77–81]. CD154 is a type 2 transmembrane protein which can be cleaved to yield a soluble form [80]. CD154 protein has been detected on platelets, CD4, CD8, and γδ-T cells.
Therapeutic interventions targeting CD40L (CD154) and CD40: the ...
CD40 was originally identified as a receptor on B-cells that delivers contact-dependent T helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal role played by CD40-CD40L interaction is illustrated by the defects …