CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage.

2020年8月11日 · CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly expressed in many tumors and endothelial cells.

2019年4月18日 · CD146 (cluster of differentiation 146) expression. CD146 is highly present at the junction but outside tight and adherent junctions. CD146 is a transmembrane glycoprotein that contains 5 immunoglobulin-like domains.

CD146 (cluster of differentiation 146) is an adhesion molecule that is expressed by different cells constituting vessels, particularly endothelial cells. The last 30 years of research in this field have shown that CD146 plays a key role in the control of several vessel functions.

In this study, CEC were analyzed by flow cytometry applying three different panels composed of the antibodies CD144, CD146, CD31, CD133, CD45 and anti-Vascular endothelial growth factor receptor-2 (VEGFR2), remembering that these cells can present more than one phenotype.

Because of the heterogeneity of CD146 expression in MSC populations, we compared CD146 −/Low and CD146 High cells from clonal and sorted MSCs after culture expansion to determine whether this expression is associated with specific functions.

2013年4月28日 · CD146 has increasingly become an important molecule, especially identified as a novel bio-marker for angiogenesis and for cancer. Here we have reviewed the dynamic research of CD146, particularly newly identified functions and the underlying mechanisms of CD146.

CD146 (MCAM, MUC18, S-Endo1) is a transmembrane glycoprotein belonging to both CAM and mucin families. It exists as different splice variants and is cleaved from the membrane by metalloproteases to generate a soluble form. CD146 is expressed by ...

CD146, also known as melanoma cell adhesion molecule (MCAM), is a membrane glycoprotein and member of the immunoglobulin gene superfamily. It is normally expressed by vascular endothelial cells, smooth muscle cells, and pericytes.

2019年4月18日 · CD146 (cluster of differentiation 146) is an adhesion molecule that is expressed by different cells constituting vessels, particularly endothelial cells. The last 30 years of research in this field have shown that CD146 plays a key role in the control of several vessel functions.