Jun 13, 2024 · CD138 is expressed in most triple negative breast cancers (TNBC). The increased expression of CD138 may contribute to the formation of a tumor supportive microenvironment, …

"CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms". American Journal of Clinical Pathology. 121 (2): 254–263. doi: 10.1309/617D-WB5G-NFWX-HW4L.

5 days ago · CD138, also known as syndecan-1, is a key surface marker of plasma cells with critical roles in immune function. It is involved in cell adhesion, signaling, and interactions within the bone marrow microenvironment. Given its significance, CD138 is a valuable tool in both research and clinical diagnostics. Understanding how CD138 influences plasma cell behavior …

CD138 is a protein found on the surface of certain cells in the body. It plays a role in cell communication and adhesion, which means it helps cells stick together and send signals to …

Sep 12, 2019 · Recognizing the presence of CD138 − PCM combined with morphology and other plasma cell markers, such as CD38 and MUM1, will be helpful for a correct diagnosis.

Our observations suggest that low CD138 expression relates to i) poor prognosis, ii) immature phenotype and iii) low sensitivity to lenalidomide. The observed distinct characteristics of CD138 low MM cells, suggest this should be recognized as a new clinical entity.

Mar 3, 2025 · Background We incidentally observed CD138 (syndecan-1) expression in a cellular neurothekeoma (CNT) and sought to investigate whether this is a consistent finding in these tumors. Methods We evalu...

We have found that the canonical surface marker of ASCs, CD138 (syndecan-1), which is upregulated during ASC maturation, is required in a cell-intrinsic manner to mount an effective long-term humoral immune response following immunization.

Aug 22, 2019 · Blocking CD138 enhances myeloma sensitivity to bortezomib chemotherapy and significantly reduces tumor size compared to bortezomib treatment alone. Thus, our data show that CD138 surface...

One such protein is CD138, recognized for its pivotal role on plasma cells and select tumor cells. This article ventures into the profound implications of CD138, presenting a deep dive into its functions, its ties to various diseases, and exploring its promising therapeutic potentials.