CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as …

2025年1月9日 · CD11c dendritic cells encompass a variety of subtypes, each with distinct origins, phenotypes, and roles in the immune system. These subtypes contribute to a nuanced orchestration of immune responses, ensuring both effective pathogen defense and maintenance of immune homeostasis.

It can be employed to determine the subsets of dendritic cells (DC) in the immune system (see CD11c expression in human and murine immune system), but CD11c may be more than a marker for DC cells (see CD11c and inflammation).

The leukocyte integrin CD11c is a myeloid marker expressed on most DCs (Table 1). CD11c + DCs can be further subdivided by their expression of CD8α, the alpha chain of the T-cell co-receptor CD8 (see [2] for a recent review of DCs).

2021年5月11日 · CD11c+ CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity (Diabetes 2010;59:1648) Clinical features: Associated with good prognosis in B-CLL

CD11c + T-bet + atypical B cells (ABCs) have been identified in the context of vaccination, acute and chronic infections and autoimmune disease. However, the origins and functions of ABCs remain elusive.

CD11c plays a crucial role in cellular adherence, migration, and phagocytosis. Furthermore, it has been linked to inflammation and immune responses in autoimmune diseases such as rheumatoid arthritis or multiple sclerosis.

2018年6月26日 · CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4.

2021年3月12日 · Circulating CD11c + B cells are a key phenomenon in certain types of autoimmunity but have also been described in the context of regular immune responses (i.e., infections, vaccination). Using mass cytometry to profile 46 different markers on individual immune cells, we systematically init …

2023年4月3日 · The data from CD11c KO mice revealed that CD11c affected ROS irrespective of maturation stage (Figure 3B). In line with this finding, more ROS production was observed in mature KI neutrophils compared with mature WT neutrophils ( Figure 5 H).