
Integrin alpha X - Wikipedia
CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as …
CD11c Dendritic Cells: Subtypes and Their Immune Functions
2025年1月9日 · CD11c dendritic cells encompass a variety of subtypes, each with distinct origins, phenotypes, and roles in the immune system. These subtypes contribute to a nuanced orchestration of immune responses, ensuring both effective pathogen defense and maintenance of immune homeostasis.
CD11c - more than a marker for dendritic cells in histopathology
It can be employed to determine the subsets of dendritic cells (DC) in the immune system (see CD11c expression in human and murine immune system), but CD11c may be more than a marker for DC cells (see CD11c and inflammation).
CD11c - an overview | ScienceDirect Topics
The leukocyte integrin CD11c is a myeloid marker expressed on most DCs (Table 1). CD11c + DCs can be further subdivided by their expression of CD8α, the alpha chain of the T-cell co-receptor CD8 (see [2] for a recent review of DCs).
Pathology Outlines - CD10-19
2021年5月11日 · CD11c+ CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity (Diabetes 2010;59:1648) Clinical features: Associated with good prognosis in B-CLL
The development and function of CD11c - PubMed Central (PMC)
CD11c + T-bet + atypical B cells (ABCs) have been identified in the context of vaccination, acute and chronic infections and autoimmune disease. However, the origins and functions of ABCs remain elusive.
Cheat Sheet to CD11c: Dendritic Cell Marker Explained
CD11c plays a crucial role in cellular adherence, migration, and phagocytosis. Furthermore, it has been linked to inflammation and immune responses in autoimmune diseases such as rheumatoid arthritis or multiple sclerosis.
Critical role of integrin CD11c in splenic dendritic cell ... - PubMed
2018年6月26日 · CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4.
Deep Phenotyping of CD11c+ B Cells in Systemic Autoimmunity and ...
2021年3月12日 · Circulating CD11c + B cells are a key phenomenon in certain types of autoimmunity but have also been described in the context of regular immune responses (i.e., infections, vaccination). Using mass cytometry to profile 46 different markers on individual immune cells, we systematically init …
CD11c regulates neutrophil maturation | Blood Advances
2023年4月3日 · The data from CD11c KO mice revealed that CD11c affected ROS irrespective of maturation stage (Figure 3B). In line with this finding, more ROS production was observed in mature KI neutrophils compared with mature WT neutrophils ( Figure 5 H).