
KIT (gene) - Wikipedia
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth …
Pathology Outlines - CD117
2022年6月9日 · CD117 is a proto-oncogene activated in GIST tumors, receptor for kit protein, a 145 kD tyrosine kinase growth factor receptor protein
Definition of CD117 - NCI Dictionary of Cancer Terms
CD117 is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and stem cell factor receptor. A protein found on the surface of many different types of cells. It binds to a …
CD117/CD34 expression in leukemic blasts - PubMed
CD117 is present on approximately 4% of normal bone marrow mononuclear cells and in acute myelogenous leukemia (AML) and chronic myelogenous leukemia in myeloid blast crisis, but …
KIT (CD117): a review on expression in normal and neoplastic …
CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor.
CD117 - an overview | ScienceDirect Topics
CD117, also known as c-kit, is a tyrosine kinase receptor that is expressed in most hemopoietic stem and progenitor cells, as well as mast cells. It is a marker used for the detection of mast …
CD117 - MyPathologyReport.ca
CD117, also known as c-kit, is a protein that acts as a receptor on the surface of specific cells in the body. It is involved in cell growth, survival, and development, particularly in cells that form …
CD117: a sensitive marker for gastrointestinal stromal tumors that …
CD117, the c-kit proto-oncogene product, is expressed in subsets of hematopoietic stem cells, mast cells, melanocytes, and interstitial cells of Cajal of the GI tract. CD117 was almost …
CD117 Expression Is Associated with Cytogenetic and Molecular …
2019年11月13日 · The CD117 (c-KIT) receptor tyrosine kinase is expressed on the cell surface of hematopoietic stem cells and its signaling is important in cell survival, proliferation and …
Selective hematopoietic stem cell ablation using CD117 ... - Nature
2019年2月6日 · Here we show that a single dose of a CD117-antibody-drug-conjugate (CD117-ADC) to saporin leads to > 99% depletion of host HSCs, enabling rapid and efficient donor …