CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

The CD1 molecules bind and present amphipathic lipid antigens for recognition by T-cell receptors.

CD1 molecules are cell surface glycoproteins expressed mainly by white blood cells, including B lymphocytes, macrophages and dendritic cells (DC). They consist of two chains: β 2 microglobulin (β 2 m), also found in MHC class I molecules, and a heavy chain containing three extracellular domains (α1–α3).

The CD1 proteins are a family of non-polymorphic, MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions. Recent studies have provided new insight into the identity of ...

Here, we summarize the molecular properties of the CD1 isoforms, their lipid antigens, and CD1-restricted T cells, with particular focus on CD1a. We then discuss the roles that CD1a-reactive T cells play in several diseases.

Sep 11, 2023 · CD1s are constitutively expressed by professional and nonprofessional antigen-presenting cells in mucosal tissues, namely, the skin, lung, and intestine. This suggests that CD1-reactive T cells...

Jan 1, 2003 · Crystal structures have been determined for two CD1 proteins. These show that the mouse CD1d antigen-binding groove has two pockets, which can accommodate lipids with an overall length of up to...

CD1 molecules are well known for their role in binding and presenting lipid antigens to mediate the activation of CD1-restricted T cells.

This review summarizes the major features of CD1 genes and proteins, the patterns of intracellular trafficking of CD1 molecules, and how they sample different intracellular compartments for self- and foreign lipids.

The CD1 molecules bind and present amphipathic lipid antigens for recognition by T-cell receptors. Here, we outline the recent advances in our understanding of how the processes of CD1 assembly, trafficking, lipid-antigen binding and T-cell activation are achieved and the new insights into how lipid antigens differentially elicit CD1-restricted ...