
CCT2 is an aggrephagy receptor for clearance of solid protein ...
2022年4月14日 · CCT2 associates with aggregation-prone proteins independent of cargo ubiquitination and interacts with autophagosome marker ATG8s through a non-classical VLIR motif. In addition, CCT2 regulates aggrephagy independently of the ubiquitin-binding receptors (P62, NBR1, and TAX1BP1) or chaperone-mediated autophagy.
生命学院葛亮课题组发现新型聚集体自噬受体CCT2介导固态聚集体 …
2022年4月2日 · CCT2是分子伴侣Chaperonin复合体的一个亚基,与复合体一起作为分子伴侣帮助错误折叠的蛋白正确地折叠。 研究发现,CCT2是以单体形式介导聚集体自噬的,因为只有单体形式的CCT2能够暴露出与LC3的结合位点VLIR 结构域。
The essential role of CCT2 in the regulation of aggrephagy
Here, in this mini review, we highlights the essential role of CCT2, a subunit of the chaperonin TRiC complex, in regulating aggrephagy. CCT2, traditionally viewed as a molecular chaperone, has emerged as a novel autophagy receptor that specifically targets solid …
CCT2 Gene - GeneCards | TCPB Protein | TCPB Antibody
2024年12月24日 · CCT2 (Chaperonin Containing TCP1 Subunit 2) is a Protein Coding gene. Diseases associated with CCT2 include Aniridia 1 and Bardet-Biedl Syndrome 18. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding.
专家点评丨新型聚集体自噬受体CCT2的作用与机制
2022年4月2日 · CCT2是分子伴侣TRiC (TCP-1 ring complex) 复合体的一个亚基,TRiC是一个由8种亚基组成的十六聚体,在细胞内负责约10%的蛋白的正确折叠 【10】 。研究人员发现, CCT2在介导聚集体自噬的过程中不依赖于TRiC,而是以单体的形式发挥作用 。当处于复合体中时,CCT2与LC3的 ...
CCT2, a newly identified aggrephagy receptor in mammals
A recent study from Ge lab reported the TRiC subunit CCT2 (chaperonin containing TCP1 subunit 2) as the first identified specific aggrephagy receptor in mammals. The switch of CCT2's role from a chaperonin to a specific aggrephagy receptor is achieved by CCT2 monomer formation.
浙江大学《Cell》,合作发文发现新型聚集体自噬受体CCT2介导固 …
CCT2是分子伴侣Chaperonin复合体的一个亚基,与复合体一起作为分子伴侣帮助错误折叠的蛋白正确折叠。进一步研究发现,CCT2以单体形式介导聚集体自噬,因为只有单体形式的CCT2能够暴露出与LC3的结合位点VLIR 结构域。
科学网—《细胞》:清华大学葛亮课题组发现并阐释新型聚集体自噬受体CCT2 …
2022年4月2日 · CCT2作为细胞内一种重要的分子伴侣chaperonin复合体的一个亚基,在介导错误折叠蛋白正确地折叠中发挥重要作用。 而一旦错误折叠蛋白过度积累形成了聚集体,分子伴侣的作用就大打折扣了。
Cell:清华大学葛亮团队等发现新型聚集体自噬受体CCT2介导固态 …
2022年4月1日,清华大学生命学院葛亮课题组在 Cell 期刊在线发表题为:CCT2 is an aggrephagy receptor for clearance of solid protein aggregates的研究论文。该研究发现了一种新型的聚集体自噬受体CCT2在清除固态蛋白聚集体中的重要作用。
CCT2 is an aggrephagy receptor for clearance of solid protein ...
2022年4月1日 · CCT2 associates with aggregation-prone proteins independent of cargo ubiquitination and interacts with autophagosome marker ATG8s through a non-classical VLIR motif. In addition, CCT2 regulates aggrephagy independently of the ubiquitin-binding receptors (P62, NBR1, and TAX1BP1) or chaperone-mediated autophagy.